Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Benzoyl peroxide
Drug ID BADD_D00241
Description Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [adapalene].[L33314] After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.[A18903,A233859] This treatment decreases keratin and sebum around follicles, as well as increasing turnover of epithelial cells.[A234059,A234064,A234069] Benzoyl peroxide, in combination with erythromycin, was granted FDA approval on 26 October 1984.[L33264]
Indications and Usage Benzoyl peroxide is formulated with antibiotics such as [erythromycin][L33264] and [clindamycin][L33269] for the treatment of acne vulgaris. Benzoyl peroxide is formulated as a number of topical products for the treatment of acne.[L33249, L33299] Benzoyl peroxide is also indicated in combination with [tretinoin] for the treatment of acne vulgaris in patients aged nine years and older.[L34869]
Marketing Status approved
ATC Code D10AE01
DrugBank ID DB09096
KEGG ID D03093
MeSH ID D001585
PubChem ID 7187
TTD Drug ID D04DXN
NDC Product Code 73010-900; 82172-230; 51927-3085; 10742-1205; 10742-1397; 10742-8304; 10742-8353; 10742-8356; 21130-730; 24470-901; 42192-161; 45802-318; 51316-048; 67234-035; 69968-0026; 70162-103; 71399-9236; 71399-9474; 71421-101; 71792-101; 71819-011; 71819-013; 11410-011; 11673-152; 14222-1610; 41250-229; 41250-348; 45802-216; 49035-264; 49967-238; 50066-052; 50090-1720; 50594-229; 55621-017; 0316-0264; 0363-0264; 0363-0467; 65113-2372; 67402-021; 68071-2307; 68343-123; 70162-102; 0536-1056; 70707-155; 71397-821; 76144-610; 76162-264; 78518-295; 80861-006; 81136-023; 0869-0264; 10742-1201; 11090-223; 11118-0264; 14222-1600; 39765-034; 41250-567; 49825-129; 51326-112; 58400-001; 0299-4125; 0316-0228; 59958-402; 69748-641; 69968-0043; 0536-1259; 71131-100; 71804-853; 0299-5890; 59958-401; 0363-1522; 63550-193; 64760-712; 65113-2373; 69842-637; 69842-646; 69968-0212; 0536-1261; 70707-101; 70707-151; 70707-211; 77924-002; 79481-0023; 80861-003; 82575-122; 82746-320; 47643-002; 10742-8397; 11410-005; 14222-1620; 24470-900; 0187-0194; 51316-047; 0299-4137; 0363-0116; 0363-0266; 62032-611; 63824-437; 63824-438; 69842-023; 70707-711; 71397-822; 72288-229; 72288-264; 73246-001; 10742-1313; 10742-8293; 11410-012; 11410-046; 24470-911; 30142-264; 35573-454; 41250-264; 42546-016; 0187-0201; 57627-202; 0299-4606; 0363-0137; 67405-825; 68062-9107; 68062-9109; 69842-571; 69968-0720; 0536-1058; 70764-106; 71399-9478; 71804-852; 71817-858; 80861-010; 80861-013; 80861-112; 10738-034; 10742-1202; 11410-040; 11673-149; 11822-6184; 30142-877; 35192-017; 35573-453; 43479-105; 45802-280; 49527-997; 51326-113; 0295-0010; 0363-0256; 62742-4212; 63824-433; 0536-1055; 70764-107; 71421-102; 83101-004; 10742-8355; 10812-975; 42192-163; 42851-087; 49035-132; 49035-829; 51326-111; 51531-9071; 52063-709; 58400-009; 0363-0229; 62742-4075; 67226-2050; 69968-0164; 69968-0653; 0536-1057; 0536-1351; 70707-200; 70707-212; 72288-525; 73350-105; 76144-611; 76162-229; 78518-013; 79903-061; 47643-003; 10742-1301; 10742-1314; 10742-8354; 68634-004; 42192-162; 45802-308; 49035-229; 50090-1792; 51326-412; 55910-264; 0316-0227; 62742-4208; 64760-732; 69842-081; 69842-137; 0536-1129; 71295-102; 71804-230; 72957-001; 76458-333; 80861-002; 47643-001; 10742-1203; 10742-1206; 14222-2120; 41250-347; 53755-392; 0363-0153; 63940-063; 64760-704; 64760-776; 67405-830; 68634-068; 68726-168; 69842-076; 70707-152; 71295-101; 71399-9234; 71687-0011; 72288-526; 72811-137; 73010-127; 78863-1180; 79481-0022; 0869-0229; 17129-002; 11673-088; 11822-7701; 45802-101; 49967-076; 56152-4009; 56152-4012; 58400-003
UNII W9WZN9A0GM
Synonyms Benzoyl Peroxide | Peroxide, Benzoyl | Diphenylglyoxal Superoxide | Superoxide, Diphenylglyoxal | Benzoyl Superoxide | Superoxide, Benzoyl | Dibenzoyl Peroxide | Peroxide, Dibenzoyl | PanOxyl
Chemical Information
Molecular Formula C14H10O4
CAS Registry Number 94-36-0
SMILES C1=CC=C(C=C1)C(=O)OOC(=O)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acne23.02.01.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000599%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000599%Not Available
Application site erythema12.07.01.001; 08.02.01.001; 23.03.06.0050.001397%Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.0040.000399%Not Available
Application site pruritus12.07.01.005; 08.02.01.005; 23.03.12.0040.000599%Not Available
Application site rash23.03.13.008; 12.07.01.016; 08.02.01.016--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Asthenia08.01.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cough22.02.03.0010.000878%
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.000599%Not Available
Dermatitis bullous23.03.01.002--
Dermatitis contact10.01.01.003; 23.03.04.004; 12.03.01.0400.000798%Not Available
Drug ineffective08.06.01.0060.001556%Not Available
Dry skin23.03.03.0010.002035%
Dyspnoea02.11.05.003; 22.02.01.0040.000399%
Erythema23.03.06.0010.002155%Not Available
Erythema multiforme10.01.03.015; 23.03.01.0030.000399%
Erythema of eyelid23.03.06.006; 06.04.04.0030.000399%Not Available
Eye swelling06.08.03.003--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.000399%
Feeling hot08.01.09.009--Not Available
Hypersensitivity10.01.03.0030.000798%
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
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