Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Weight fluctuation14.03.02.002--Not Available
Precancerous skin lesion23.01.06.0040.000471%Not Available
General physical health deterioration08.01.03.0180.005808%Not Available
Tachyarrhythmia02.03.02.0080.000785%Not Available
Muscle fatigue15.05.03.0060.000314%Not Available
Left ventricular dysfunction02.04.02.0110.000471%
Bradyarrhythmia02.03.02.0150.001570%Not Available
Shock haemorrhagic24.06.02.014; 14.05.05.0030.000471%Not Available
Muscle tightness15.05.03.0070.000314%Not Available
Balance disorder08.01.03.081; 17.02.02.007--Not Available
Dysstasia15.03.05.011; 08.01.03.089; 17.02.02.0120.000471%Not Available
Ventricular hypokinesia02.04.02.0130.000628%Not Available
Skin tightness23.03.03.0180.000314%Not Available
Lower gastrointestinal haemorrhage07.12.03.011; 24.07.02.0300.000471%
Exercise tolerance decreased08.01.03.0360.000471%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.0150.001413%Not Available
Haemodynamic instability24.03.02.0060.000628%Not Available
Ear discomfort04.03.01.0050.000314%Not Available
Eye pruritus06.04.05.0060.000785%Not Available
Diastolic dysfunction02.04.02.0220.000314%Not Available
Cardiac flutter02.03.02.0120.000785%Not Available
Musculoskeletal stiffness15.03.05.0270.001256%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.000471%Not Available
Growth retardation15.03.05.016; 14.03.02.031; 05.03.02.0070.000314%
Affect lability19.04.01.001--Not Available
Cerebral disorder17.02.10.0170.000628%Not Available
Foetal death18.01.02.003; 08.04.01.0110.000314%
Pulmonary mass22.02.07.004--Not Available
Cutaneous lupus erythematosus15.06.02.007; 23.03.02.008; 10.04.03.0070.000471%Not Available
The 15th Page    First    Pre   15 16 17 18 19    Next   Last    Total 19 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene