Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia oral07.05.05.035; 17.02.06.0080.000314%Not Available
Toxic skin eruption12.03.01.073; 23.03.05.003; 10.01.01.0080.001099%Not Available
Pulseless electrical activity02.03.04.0200.000471%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Gastrointestinal toxicity12.03.01.019; 07.08.03.0060.000471%Not Available
Congenital eye disorder06.08.03.011; 03.01.01.002--Not Available
Juvenile idiopathic arthritis10.04.06.004; 15.01.03.0040.000314%Not Available
Angiopathy24.03.02.007--Not Available
Urine output increased13.13.03.002--Not Available
Hot flush21.02.02.001; 24.03.01.005; 08.01.03.0270.001413%
Ventricular failure02.05.01.0070.000628%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.000628%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.000471%Not Available
Embolism24.01.01.009--
Infarction24.04.02.0170.000314%Not Available
Limb discomfort15.03.04.0140.000471%Not Available
Intervertebral disc degeneration15.10.01.0020.000471%Not Available
Ischaemia24.04.02.004--Not Available
Ischaemic stroke24.04.06.010; 17.08.01.0180.001727%Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Sudden hearing loss04.02.01.0090.001099%Not Available
Abnormal behaviour19.01.01.0010.000785%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.0010.001633%
Purine metabolism disorder14.09.01.007--Not Available
Respiratory disorder neonatal22.11.01.002; 18.04.09.0020.000628%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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