Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Small for dates baby18.04.02.0020.003925%Not Available
Trifascicular block02.03.01.0150.000628%Not Available
Ureteric stenosis20.06.01.0100.000314%Not Available
Live birth18.08.02.0070.000471%Not Available
Bradycardia neonatal18.04.07.004; 02.03.02.0190.001099%Not Available
Bifascicular block02.03.01.0200.000628%Not Available
Subacute cutaneous lupus erythematosus10.04.03.012; 23.03.02.020; 15.06.02.0120.000471%Not Available
Sopor19.02.04.002; 17.02.04.0210.001570%Not Available
Gastrointestinal ischaemia24.04.08.007; 07.15.02.0050.000314%Not Available
Lung hyperinflation22.12.01.0050.000471%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000942%Not Available
Foot deformity15.10.03.0050.000314%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000471%Not Available
Nodular rash23.03.13.0210.000314%Not Available
BRASH syndrome14.05.03.005; 02.03.02.0300.000471%Not Available
Cerebral venous sinus thrombosis24.01.04.021; 17.08.03.0060.000314%Not Available
Drug ineffective for unapproved indication12.09.02.002; 08.06.01.038--Not Available
Dyschromatopsia06.02.09.0030.000471%Not Available
Gait inability17.02.05.069; 08.01.02.0110.000785%Not Available
Intestinal pseudo-obstruction07.02.02.0200.000471%Not Available
Left ventricular dilatation02.04.02.0440.000471%Not Available
Malignant dysphagia07.01.06.034; 16.32.03.0400.000314%Not Available
Neonatal deafness18.04.01.023; 04.02.01.0170.000628%Not Available
Obstructive pancreatitis09.02.02.006; 07.18.01.0130.000628%Not Available
Pseudofolliculitis23.02.06.0130.000314%Not Available
Pseudohyponatraemia14.05.04.0140.000314%Not Available
Symptom recurrence08.01.03.101--Not Available
Tachycardia induced cardiomyopathy02.04.01.0180.000314%Not Available
Therapeutic product effect decreased08.06.01.050--Not Available
Therapeutic product effect incomplete08.06.01.052--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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