Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol fumarate
Drug ID BADD_D00278
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D00634
MeSH ID D017298
PubChem ID 6917733
TTD Drug ID D0K3ZR
NDC Product Code 61919-787; 52817-270; 63187-871; 68071-5097; 52817-271; 65862-087; 10920-571; 62332-603; 71335-1678; 65862-380; 65862-086; 29300-127; 65085-0051; 70954-455; 50268-127; 53747-009; 66064-1004; 52932-0720; 57451-1192; 62332-604; 38779-3142; 29300-126; 63629-6907; 70954-456; 63629-5173; 68071-1582
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C22H35NO8
CAS Registry Number 104344-23-2
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intermittent claudication24.04.03.001--Not Available
Lacrimation disorder06.08.02.010--Not Available
Laryngospasm22.04.02.002--
Libido decreased21.03.02.005; 19.08.03.001--
Malaise08.01.01.003--
Mesenteric artery thrombosis24.01.08.003; 07.15.02.008--Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Oedema08.01.07.006; 14.05.06.010--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Peripheral coldness24.04.03.006; 08.01.09.010--Not Available
Peyronie's disease21.12.01.002--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count decreased13.01.04.001--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Psoriasis23.03.14.002; 10.02.01.036--Not Available
Purpura24.07.06.005; 01.01.04.003; 23.06.01.004--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal colic20.02.03.010--
Respiratory distress22.02.01.012--Not Available
Restlessness19.11.02.002; 17.02.05.021--
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