Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol fumarate
Drug ID BADD_D00278
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D00634
MeSH ID D017298
PubChem ID 6917733
TTD Drug ID D0K3ZR
NDC Product Code 61919-787; 52817-270; 63187-871; 68071-5097; 52817-271; 65862-087; 10920-571; 62332-603; 71335-1678; 65862-380; 65862-086; 29300-127; 65085-0051; 70954-455; 50268-127; 53747-009; 66064-1004; 52932-0720; 57451-1192; 62332-604; 38779-3142; 29300-126; 63629-6907; 70954-456; 63629-5173; 68071-1582
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C22H35NO8
CAS Registry Number 104344-23-2
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rhinitis11.01.13.004; 22.07.03.006--
Sinusitis22.07.03.007; 11.01.13.005--
Skin irritation23.03.04.009--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope02.01.02.008; 24.06.02.012; 17.02.04.008--
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Vertigo17.02.12.002; 04.04.01.003--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight increased13.15.01.006--
White blood cell count decreased13.01.06.012--
Hypoacusis04.02.01.006--
Balance disorder17.02.02.007--Not Available
Blood phosphorus increased13.11.01.016--Not Available
Affect lability19.04.01.001--Not Available
Intraocular pressure test13.07.04.011--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Oropharyngeal pain22.02.05.022; 07.05.05.004--
The 4th Page    First    Pre   4    Total 4 Pages