Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Butabarbital
Drug ID BADD_D00319
Description Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.[A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613]
Indications and Usage Butabarbital is indicated for use as a sedative or hypnotic.[L13613] Butabarbital should not be used to treat insomnia for longer than 2 weeks.[L13613]
Marketing Status approved; illicit
ATC Code Not Available
DrugBank ID DB00237
KEGG ID D03180
MeSH ID C084833
PubChem ID 2479
TTD Drug ID D0A4JK
NDC Product Code 61960-2400
UNII P0078O25A9
Synonyms secbutabarbital | butabarbital | secumalum | butabarbitone | secbutobarbitone | Butisol Sodium | Butisol | Sarisol | secbutabarbital sodium | butabarbital sodium | 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt
Chemical Information
Molecular Formula C10H16N2O3
CAS Registry Number 125-40-6
SMILES CCC(C)C1(C(=O)NC(=O)NC1=O)CC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Feeling abnormal08.01.09.014--Not Available
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatocellular injury09.01.07.008--Not Available
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Loss of consciousness17.02.04.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Rash23.03.13.001--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
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