Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Butabarbital sodium
Drug ID BADD_D00320
Description Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.[A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613]
Indications and Usage Butabarbital is indicated for use as a sedative or hypnotic.[L13613] Butabarbital should not be used to treat insomnia for longer than 2 weeks.[L13613]
Marketing Status approved; illicit
ATC Code Not Available
DrugBank ID DB00237
KEGG ID D00699
MeSH ID C084833
PubChem ID 23690439
TTD Drug ID D0A4JK
NDC Product Code 61960-6500
UNII 9WTD50I918
Synonyms secbutabarbital | butabarbital | secumalum | butabarbitone | secbutobarbitone | Butisol Sodium | Butisol | Sarisol | secbutabarbital sodium | butabarbital sodium | 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt
Chemical Information
Molecular Formula C10H15N2NaO3
CAS Registry Number 143-81-7
SMILES CCC(C)C1(C(=O)NC(=NC1=O)[O-])CC.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.008--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Ataxia17.02.02.001; 08.01.02.004--
Bradycardia02.03.02.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hyperkinesia17.01.02.008--Not Available
Hypotension24.06.03.002--
Hypoventilation22.02.01.007--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.11.04.015--
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Vomiting07.01.07.003--
Mental disorder19.07.01.002--Not Available
Liver injury12.01.17.012; 09.01.07.022--Not Available
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