Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status approved
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 59762-1005; 47848-009; 14096-153; 23155-823; 70512-860; 50090-5834; 0093-5420; 50742-118
UNII LL60K9J05T
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blindness06.02.10.003; 17.17.01.0030.009609%Not Available
Blood creatinine increased13.13.01.004--
Bone disorder15.02.04.0040.004804%Not Available
Bone pain15.02.01.0010.004804%
Bradycardia02.03.02.0020.004804%Not Available
Breast atrophy21.05.04.0050.004804%
Breast pain21.05.05.0030.012972%
Bronchitis22.07.01.001; 11.01.09.001--
Burning sensation17.02.06.001; 08.01.09.0290.004804%Not Available
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.012011%Not Available
Cardiomegaly02.04.02.0010.007207%Not Available
Cerebrospinal fluid leakage17.02.05.001; 12.01.10.0040.100893%
Cholecystitis acute09.03.01.0030.007207%Not Available
Cholelithiasis09.03.01.0020.009609%Not Available
Condition aggravated08.01.03.0040.039396%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Congenital anomaly03.02.01.001--Not Available
Constipation07.02.02.0010.039877%
Delusion19.10.01.0010.009609%
Delusional disorder, unspecified type19.03.03.0020.004804%Not Available
Depressed level of consciousness17.02.04.0020.004804%
Depressed mood19.15.02.0010.021620%Not Available
Depression19.15.01.0010.028346%
Dermatitis23.03.04.002--Not Available
Developmental delay19.07.05.003; 08.01.03.0370.004804%Not Available
Diabetes insipidus14.05.07.003; 05.03.03.0040.004804%Not Available
Diabetes mellitus05.06.01.001; 14.06.01.0010.009609%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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