Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status approved
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 59762-1005; 47848-009; 14096-153; 23155-823; 70512-860; 50090-5834; 0093-5420; 50742-118
UNII LL60K9J05T
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retroperitoneal fibrosis10.02.01.026; 07.07.03.003; 20.06.01.006--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.0100.004804%
Sleep disorder19.02.04.0010.007207%Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.007207%Not Available
Stillbirth18.01.02.002; 08.04.01.0060.016815%Not Available
Stress19.06.02.0040.004804%Not Available
Subarachnoid haemorrhage24.07.04.004; 17.08.01.010; 12.01.10.0110.019218%Not Available
Suicidal ideation19.12.01.0030.015374%
Swelling08.01.03.0150.007207%Not Available
Syncope24.06.02.012; 17.02.04.008; 02.11.04.015--
Tension19.06.02.005--Not Available
Therapeutic response decreased08.06.01.0160.015374%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.010570%Not Available
Throat irritation22.12.03.029; 07.05.05.037--Not Available
Toothache07.09.06.001--
Tricuspid valve incompetence02.07.05.0010.014413%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary incontinence20.02.02.010; 17.05.01.0080.004804%
Urinary tract infection20.08.02.001; 11.01.14.004--
Vasospasm24.04.02.002--Not Available
Vertigo17.02.12.002; 04.04.01.0030.010570%
Visual acuity reduced06.02.10.012; 17.17.01.0110.009609%
Visual field defect17.17.01.001; 06.02.07.0030.017776%Not Available
Visual impairment06.02.10.0130.015374%Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
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ADReCS-Target
Drug Name ADR Term Target
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