| Drug Name |
Caffeine |
| Drug ID |
BADD_D00332 |
| Description |
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.[T716]
The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely.[A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716] |
| Indications and Usage |
Caffeine is indicated for the short term treatment of apnea of prematurity in infants and off label for the prevention and treatment of bronchopulmonary dysplasia caused by premature birth.[T716,L9851] In addition, it is indicated in combination with sodium benzoate to treat respiratory depression resulting from an overdose with CNS depressant drugs.[L9899] Caffeine has a broad range of over the counter uses, and is found in energy supplements, athletic enhancement products, pain relief products, as well as cosmetic products.[T716,L9854,L9872] |
| Marketing Status |
approved |
| ATC Code |
D11AX26; N06BC01 |
| DrugBank ID |
DB00201
|
| KEGG ID |
D00528; D01453
|
| MeSH ID |
D002110
|
| PubChem ID |
2519
|
| TTD Drug ID |
D0B3HD
|
| NDC Product Code |
65724-4013; 15579-201; 21130-944; 52389-656; 53943-320; 57243-226; 70000-0409; 71179-018; 10267-5010; 58624-0316; 65724-4004; 65724-4008; 21130-226; 46122-457; 56062-030; 63868-114; 41163-226; 62011-0340; 0363-5009; 68998-076; 69842-500; 72036-020; 70677-1126; 41250-320; 55910-226; 56062-409; 69168-076; 69842-509; 70677-0021; 58624-0304; 11822-2260; 63083-1508; 66715-5930; 30142-726; 41163-434; 41520-708; 63941-020; 66715-5830; 68016-680; 80136-855; 51552-0200; 58624-0302; 67091-117; 58624-0308; 58624-0312; 58624-0534; 65724-4012; 68210-4030; 36800-844; 49035-226; 49483-343; 52389-406; 55301-226; 0363-0226; 0363-3440; 66715-9799; 58624-0310; 65724-4000; 50804-262; 52389-155; 66715-5530; 72476-102; 76162-002; 38779-0419; 58624-0306; 58624-0314; 37808-409 |
| UNII |
3G6A5W338E
|
| Synonyms |
Caffeine | 1,3,7-Trimethylxanthine | Vivarin | Caffedrine | Coffeinum N | Percutaféine | Dexitac | Durvitan | No Doz | Percoffedrinol N | Quick-Pep | Quick Pep | QuickPep | Coffeinum Purrum |
