Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Captopril
Drug ID BADD_D00354
Description Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Indications and Usage For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
Marketing Status approved
ATC Code C09AA01
DrugBank ID DB01197
KEGG ID D00251
MeSH ID D002216
PubChem ID 44093
TTD Drug ID D0I0EG
NDC Product Code 27241-162; 31722-141; 31722-142; 0143-1171; 63629-8728; 69292-526; 53296-0031; 31722-144; 0143-1174; 60687-304; 63629-1338; 63629-8730; 0781-8061; 0904-7105; 63629-8729; 70518-3307; 71335-1918; 51552-1072; 51927-0137; 27241-160; 27241-161; 43547-363; 63629-8727; 69292-522; 71335-0826; 0781-8052; 53069-0150; 31722-143; 27241-163; 51407-601; 51407-602; 51407-603; 43547-366; 55289-344; 0781-8080; 55488-0600; 43547-364; 0781-8075; 0143-1172; 0143-1173; 43547-365; 50090-5964; 51407-600; 60687-315; 69292-524; 69292-528; 0904-7106
UNII 9G64RSX1XD
Synonyms Captopril | (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline | Lopirin | SQ-14,534 | SQ 14,534 | SQ14,534 | SQ-14534 | SQ 14534 | SQ14534 | Capoten | SQ-14,225 | SQ 14,225 | SQ14,225 | SQ-14225 | SQ 14225 | SQ14225
Chemical Information
Molecular Formula C9H15NO3S
CAS Registry Number 62571-86-2
SMILES CC(CS)C(=O)N1CCCC1C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pemphigoid23.03.01.004; 10.04.02.002--Not Available
Pemphigus23.03.01.005; 10.04.02.003--Not Available
Peptic ulcer07.04.07.001--Not Available
Pharyngeal oedema10.01.05.016; 23.04.01.016; 22.04.05.0030.001219%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Pregnancy18.08.02.004--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pulmonary eosinophilia22.01.01.009; 01.02.04.006--Not Available
Pyrexia08.05.02.0030.000975%
Rales22.12.01.011--Not Available
Rash23.03.13.001--Not Available
Rash erythematous23.03.13.0290.000732%Not Available
Rash maculo-papular23.03.13.0040.000732%
Rash pruritic23.03.13.0300.000732%Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Renal failure20.01.03.005--Not Available
Renal pain20.02.03.0030.000488%Not Available
Renovascular hypertension24.08.08.001; 20.01.08.003--Not Available
Respiratory arrest22.02.01.0090.000732%Not Available
Respiratory distress22.02.01.0120.001463%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000488%
Rhinitis22.07.03.006; 11.01.13.004--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.0010.000488%
Serum sickness12.02.08.004; 10.01.03.004--
Shock24.06.02.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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