| Drug Name |
Carbidopa |
| Drug ID |
BADD_D00359 |
| Description |
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with [levodopa]. An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy [levodopa]/carbidopa is not efficient reducing nausea.[T394]
The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014.[L5110] On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination therapy developed by Mayne Pharma in 1992.[L5113] |
| Indications and Usage |
Carbidopa is indicated with [levodopa] for the treatment of symptoms of idiopathic Parkinson disease, postencephalitic parkinsonism and symptomatic parkinsonism followed by carbon monoxide or manganese intoxication.[FDA label]
The combination therapy is administered for the reduction of [levodopa]-driven nausea and vomiting.[FDA label]
The product of carbidopa should be used in patients where the combination therapy of carbidopa/[levodopa] provide less than the adequate daily dosage.[FDA label]
As well carbidopa can be used in patients where the dosages of carbidopa and [levodopa] require individual titration.[FDA label] |
| Marketing Status |
approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB00190
|
| KEGG ID |
D00558
|
| MeSH ID |
D002230
|
| PubChem ID |
34359
|
| TTD Drug ID |
D0P7JZ
|
| NDC Product Code |
62331-014; 67628-2001; 70710-1221; 12780-4420; 15894-0040; 49452-1692; 51504-0001; 51927-0251; 62991-2848; 43386-980; 58624-0621; 16714-067; 40032-980; 65977-0131; 59651-146; 63629-9193; 70771-1355; 38779-0202; 52423-0901; 70600-018; 63415-0024; 25010-711; 43975-220; 42799-123; 63629-1932 |
| UNII |
MNX7R8C5VO
|
| Synonyms |
Carbidopa | Methyldopahydrazine | MK-486 | MK 486 | MK486 | Lodosin | Lodosyn | MK-485 | MK 485 | MK485 | Carbidopa, (S)-Isomer | Carbidopa, (R)-Isomer |
