Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchial fistula22.03.02.0110.000168%
Epiglottic oedema22.04.02.0060.000168%Not Available
IgA nephropathy20.05.01.016; 10.02.01.0630.000224%Not Available
Lymphadenopathy mediastinal22.09.03.006; 01.09.01.0250.000112%Not Available
Malignant pleural effusion22.05.04.001; 16.32.03.0140.000112%Not Available
Metastases to bone15.09.03.006; 16.22.02.0050.000672%Not Available
Metastases to lymph nodes16.22.02.006; 01.09.01.0150.000168%Not Available
Mixed deafness17.04.07.006; 04.02.01.0140.000168%Not Available
Pancreatic carcinoma metastatic16.13.10.003; 07.21.09.0060.000168%Not Available
Recurrent cancer16.16.01.0150.000168%Not Available
Seminoma21.13.02.004; 16.25.03.0020.000112%Not Available
Pericardial effusion malignant16.32.03.026; 02.06.01.0090.000112%Not Available
Metastases to meninges16.22.02.003; 17.02.10.0120.000168%Not Available
Pulmonary cavitation22.01.02.0220.000168%Not Available
Laryngeal discomfort22.12.03.0090.000112%Not Available
Thyroid cancer metastatic16.24.03.006; 05.02.05.0090.000112%Not Available
Breast cancer metastatic16.10.01.008; 21.05.01.0160.000168%Not Available
Growth hormone deficiency05.03.02.0040.000280%Not Available
Abdominal compartment syndrome24.04.09.009; 07.11.01.0170.000224%Not Available
Gastrointestinal erosion07.04.04.0090.000392%Not Available
Hormone-refractory prostate cancer21.04.02.007; 16.25.01.0040.000168%Not Available
Portal venous gas07.01.06.0330.000224%Not Available
Iris neovascularisation06.07.06.001; 24.03.07.0120.000224%Not Available
Astrocytoma, low grade17.18.04.001; 16.09.04.0010.000280%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000112%Not Available
Vasogenic cerebral oedema17.07.02.0080.000112%Not Available
Butterfly rash23.03.13.019; 15.06.02.010; 10.04.03.0100.000224%Not Available
Respiratory fatigue22.02.01.0420.000224%Not Available
Band sensation17.16.01.0040.000280%Not Available
Psychological trauma19.01.02.0170.002127%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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