Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Growth hormone deficiency05.03.02.0040.001332%Not Available
Post procedural urine leak12.02.10.008; 20.06.01.0090.001066%Not Available
Abdominal compartment syndrome24.04.09.009; 07.11.01.0170.000278%Not Available
Wound infection staphylococcal12.02.05.051; 11.02.05.0140.000533%Not Available
Gastrointestinal erosion07.04.04.0090.001865%Not Available
Escherichia infection11.02.10.0040.000799%Not Available
Klebsiella infection11.02.03.0030.000799%Not Available
Neutrophil count abnormal13.01.06.0180.002931%Not Available
Gastritis bacterial11.02.01.039; 07.19.03.0140.000533%Not Available
Portal venous gas07.01.06.0330.001598%Not Available
Iris neovascularisation24.03.07.012; 06.07.06.0010.001066%Not Available
Astrocytoma, low grade17.18.04.001; 16.09.04.0010.000799%Not Available
Quality of life decreased13.18.01.0130.000799%Not Available
Gastroenteritis norovirus11.05.22.001; 07.19.03.0170.000533%Not Available
Respiratory fatigue22.02.08.0190.001066%Not Available
Clostridium test positive13.08.01.0070.002131%Not Available
Staphylococcus test positive13.08.01.0150.000533%Not Available
Streptococcus test positive13.08.01.0160.000533%Not Available
Escherichia test positive13.08.01.0090.000799%Not Available
Pseudocellulitis23.03.04.0400.000533%Not Available
Pharyngeal paraesthesia22.04.05.018; 17.02.06.0350.001066%Not Available
Adult failure to thrive19.15.02.009; 14.03.02.020; 08.01.01.0140.000139%Not Available
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