Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status approved; investigational
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 54879-036; 43598-628; 70710-1525; 70860-223; 0781-3474; 50137-0686; 57821-002; 14593-823; 16729-545; 23155-790; 70121-1482; 76339-121; 50683-0017; 54893-0055; 68475-503; 57884-0032; 16729-548; 23155-649; 55718-139; 59651-168; 24338-050; 58621-002; 59981-034; 23155-261; 71288-126
UNII U68WG3173Y
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Acute leukaemia01.10.02.001; 16.01.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000504%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.0010.000895%
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Blood bilirubin increased13.03.04.018--
Body temperature increased13.15.01.001--Not Available
Brain abscess17.06.07.001; 11.01.03.003--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000168%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000895%Not Available
Cerebrospinal fluid leakage12.01.10.004; 17.02.05.0010.000392%
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Coma17.02.09.001--Not Available
Condition aggravated08.01.03.0040.001063%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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