Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Carvedilol phosphate
Drug ID BADD_D00375
Description Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889]
Indications and Usage Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.[L7889,L7892]
Marketing Status approved; investigational
ATC Code C07AG02
DrugBank ID DB01136
KEGG ID D03415
MeSH ID D000077261
PubChem ID 9827459
TTD Drug ID D0W9LX
NDC Product Code 12658-0570; 53873-061; 65015-884; 0007-3385; 51407-051; 63629-9634; 69784-714; 12658-0559; 12658-0596; 36974-0067; 16714-229; 51407-050; 51407-052; 69784-385; 69784-713; 72761-003; 0007-3383; 12658-0546; 53873-062; 63629-9632; 63629-9635; 69784-388; 69784-715; 71335-9707; 12658-0595; 12658-0603; 16714-228; 63629-9633; 69784-383; 53873-063; 16714-230; 51407-053; 57664-664; 57664-666; 69784-716; 12658-0412; 12658-0560; 0007-3371; 60505-3679; 63629-8794; 69784-387; 12658-0590; 53873-060; 61187-004; 16714-227; 57664-665; 63415-0127; 0007-3373; 0007-3387; 57664-663
UNII EQT531S367
Synonyms Carvedilol | Carvedilol Hydrochloride | Dilatrend | Querto | Eucardic | Carvedilol, (S)-isomer | Kredex | BM 14190 | BM-14190 | BM14190 | Carvedilol, (R)-isomer | Carvedilol, (+)-isomer | Carvedilol, (+) | Carvedilol, (+-)-isomer | Carvedilol, (-)-isomer | Carvedilol, (-) | Carvedilol, 14C-labeled | 14C-labeled Carvedilol | Carvedilol, 14C labeled | Coropres | Coreg
Chemical Information
Molecular Formula C24H29N2O8P
CAS Registry Number 374779-45-0
SMILES COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.OP(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Libido decreased21.03.02.005; 19.08.03.001--
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.004--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Muscle spasms15.05.03.004--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuralgia17.02.07.005--
Nightmare19.02.03.003--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.11.04.012--
Pancytopenia01.03.03.003--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Paresis17.01.04.008--Not Available
Periodontitis11.01.04.012; 07.09.01.002--Not Available
Peripheral ischaemia24.04.03.002--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Prothrombin level decreased13.01.02.010--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Rales22.12.01.011--Not Available
Rash erythematous23.03.13.029--Not Available
Rash maculo-papular23.03.13.004--
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