Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status approved
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 0409-2585; 0143-9923; 0781-3451; 0404-9833; 72572-055; 60505-6231; 0781-3450; 60505-6142; 60505-6143; 71872-7027; 44567-707; 44567-840; 52584-924; 71205-679; 72572-056; 60505-6243; 17337-0300; 0143-9924; 44567-120; 52584-087; 60505-6244; 67184-0560; 67184-1001; 0404-9835; 44567-706; 52584-923; 70518-3047; 0143-9262; 0404-9834; 71872-7141; 0781-3452; 0143-9139; 0143-9140; 0143-9261; 0143-9665; 0143-9983; 44567-708
UNII IHS69L0Y4T
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000122%
Abdominal pain upper07.01.05.003--
Acute hepatic failure09.01.03.0010.000073%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000073%Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.04.005--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000049%Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000982%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000462%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000559%Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.0010.000049%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000049%
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001--Not Available
Blister23.03.01.001; 12.01.06.0020.000073%Not Available
Blood alkaline phosphatase13.04.02.010--Not Available
Blood bilirubin increased13.03.04.018--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000170%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.000243%
Cardiac arrest02.03.04.0010.000146%
Cardiac failure congestive02.05.01.0020.000049%Not Available
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