Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ceftriaxone sodium
Drug ID BADD_D00406
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage Ceftriaxone is used for the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by susceptible organisms.[L15082] Organisms that are generally susceptible to ceftriaxone include S. pneumoniae, S. pyogenes (group A beta-hemolytic streptococci), coagulase-negative staphylococci, Some Enterobacter spp, H. influenzae, N. gonorrhoeae, P. mirabilis, E. coli, Klebsiella spp, M. catarrhalis, B. burgdorferi, and some oral anaerobes.[A215582]
Marketing Status approved
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D00924
MeSH ID D002443
PubChem ID 9570985
TTD Drug ID D07ACT
NDC Product Code 67184-1006; 0409-7333; 0409-7337; 70518-2301; 71205-545; 0781-3208; 66288-6100; 67184-1005; 0409-7334; 71205-710; 60505-6148; 0338-5003; 70518-0659; 0409-7332; 0409-7335; 0409-7338; 0781-3206; 60505-6149; 0781-3210; 60505-6152; 0338-5002; 0781-3207; 51065-004; 50090-0944; 60505-6151; 0781-3209; 25021-108; 50090-3838; 60505-6150; 67184-1007; 67184-1008; 0409-7336; 70518-2499; 50090-4689
UNII 023Z5BR09K
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H16N8Na2O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-] .[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Psychomotor hyperactivity17.01.02.011; 19.11.02.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal disorder20.01.02.002--Not Available
Seizure17.12.03.001--
Serum sickness12.02.08.004; 10.01.03.004--
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Stomatitis07.05.06.005--
Superinfection11.01.08.009--Not Available
Tenderness08.01.08.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Ureteric obstruction20.06.01.005--Not Available
Urine glucose false positive13.02.02.006--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Vomiting07.01.07.003--
Acute generalised exanthematous pustulosis10.01.01.034; 23.03.10.002; 12.03.01.005; 11.07.01.018--Not Available
Muscle tightness15.05.03.007--Not Available
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Induration08.01.03.020--Not Available
Genital infection fungal21.10.03.003; 11.03.05.003--Not Available
Renal impairment20.01.03.010--Not Available
Acute kidney injury20.01.03.016--
Candida infection11.03.03.021--
Hypersensitivity pneumonitis22.01.01.027; 10.01.03.056--Not Available
The 3th Page    First    Pre   3    Total 3 Pages