Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cholestyramine resin
Drug ID BADD_D00452
Description Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Indications and Usage Indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Also for the relief of pruritus associated with partial biliary obstruction.
Marketing Status approved; investigational
ATC Code C10AC01
DrugBank ID DB01432
KEGG ID D02690
MeSH ID D002792
PubChem ID 137699107
TTD Drug ID Not Available
NDC Product Code 38779-0822; 62991-2650; 55363-454; 51552-0684; 49452-2011
UNII 4B33BGI082
Synonyms Cholestyramine Resin | Cholestyramine Resins | Resin, Cholestyramine | Resins, Cholestyramine | Colestyramin | Colestyramins | Colestyramine | Colestyramines | Cholestyramine | Cholestyramines | MK-135 | MK 135 | MK135 | Questran | Questrans | Cuemid | Cuemids | Quantalan | Quantalans
Chemical Information
Molecular Formula C27H47ClN2
CAS Registry Number 11041-12-6
SMILES CCC(C)C.CCC(CC(C)C1=CC=CC=C1)C2=CC=C(C=C2)C[N+](C)(C)C.N.[Cl-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Proctalgia07.03.02.001--
Prothrombin level increased13.01.02.011--Not Available
Prothrombin time shortened13.01.02.013--Not Available
Rash23.03.13.001--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Shock24.06.02.002--Not Available
Skin irritation23.03.04.009--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Steatorrhoea07.17.01.002--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Thrombophlebitis24.01.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Ulcer08.03.06.001--Not Available
Urticaria10.01.06.001; 23.04.02.001--
Uveitis10.02.01.023; 06.04.03.003--
Vertigo17.02.12.002; 04.04.01.003--
Vitamin K deficiency14.12.03.005--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Wheezing22.03.01.009--
Xanthoma23.03.03.047; 14.08.04.010--Not Available
Acute coronary syndrome02.02.02.015; 24.04.04.011--Not Available
Foetor hepaticus09.01.05.006; 07.01.06.026--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhoidal haemorrhage24.10.02.001; 07.15.03.002--
Haemorrhage24.07.01.002--Not Available
Faecaloma07.01.03.004--Not Available
Faecalith07.01.03.007--Not Available
Arcus lipoides06.06.03.014--Not Available
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