ADReCS

Pharmaceutical Information

Drug Name	Cisplatin
Drug ID	BADD_D00474
Description	Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage	For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status	approved
ATC Code	L01XA01
DrugBank ID	DB00515
KEGG ID	D00275
MeSH ID	D002945
PubChem ID	5702198
TTD Drug ID	D0U5HU
NDC Product Code	16729-288; 25021-253; 0143-9505; 68554-0077; 0143-9504; 68001-283; 44567-509; 50711-0001; 44567-510; 63323-103; 0703-5747; 0703-5748; 44567-530; 60505-6277; 68083-163; 44567-511; 49452-2078; 54875-0001; 67184-0010; 68083-162; 70860-206; 49812-0009; 72659-864
UNII	Q20Q21Q62J
Synonyms	Cisplatin \| cis-Diamminedichloroplatinum(II) \| Platinum Diamminodichloride \| Diamminodichloride, Platinum \| cis-Platinum \| cis Platinum \| Dichlorodiammineplatinum \| cis-Diamminedichloroplatinum \| cis Diamminedichloroplatinum \| cis-Dichlorodiammineplatinum(II) \| NSC-119875 \| Platino \| Platinol \| Biocisplatinum \| Platidiam

Chemical Information

Molecular Formula	PtCl2(NH3)2
CAS Registry Number	15663-27-1
SMILES	N.N.Cl[Pt]Cl
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Arteriospasm coronary	12.02.01.031; 24.04.04.005; 02.02.02.005	0.000336%		Not Available
Arthralgia	15.01.02.001	-	-
Ascites	09.01.05.003; 07.07.01.001; 02.05.04.002	0.000728%
Aspiration	22.02.07.007	0.001142%
Asthenia	08.01.01.001	0.006067%		Not Available
Ataxia	17.02.02.001; 08.01.02.004	0.000224%
Atelectasis	22.01.02.001	0.000280%
Atrial fibrillation	02.03.03.002	0.001119%
Atrial flutter	02.03.03.003	0.000112%
Atrioventricular block complete	02.03.01.003	0.000280%
Atrioventricular block second degree	02.03.01.005	0.000112%
Auditory disorder	04.02.03.002	0.000168%		Not Available
Axonal neuropathy	17.09.03.015	0.000112%		Not Available
Blindness	17.17.01.003; 06.02.10.003	-	-	Not Available
Blood bilirubin increased	13.03.04.018	-	-
Budd-Chiari syndrome	24.01.03.001; 09.01.06.001	0.000112%
Bundle branch block right	02.03.01.011	0.000112%		Not Available
Cachexia	16.32.03.011; 14.03.02.001; 08.01.01.009	0.000280%		Not Available
Cardiac arrest	02.03.04.001	0.000783%
Cardiac failure	02.05.01.001	0.001231%
Cardiac failure acute	02.05.01.005	0.000224%		Not Available
Cardiac tamponade	02.06.01.001	0.000112%
Cardio-respiratory arrest	22.02.06.007; 02.03.04.002	0.000616%		Not Available
Cardiogenic shock	24.06.02.006; 02.05.01.003	0.000168%		Not Available
Cardiomegaly	02.04.02.001	0.000168%		Not Available
Cardiomyopathy	02.04.01.001	0.000783%		Not Available
Cellulitis	23.11.02.004; 11.02.01.001	-	-	Not Available
Cerebral arteritis	24.12.02.002; 17.08.02.004	-	-	Not Available
Cerebral atrophy	17.11.01.001	0.000112%		Not Available
Cerebral infarction	17.08.01.004; 24.04.06.002	0.000951%		Not Available

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