Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citric acid
Drug ID BADD_D00477
Description A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. Citric acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120]
Indications and Usage Not Available
Marketing Status approved; nutraceutical; vet_approved
ATC Code A09AB04
DrugBank ID DB04272
KEGG ID D01222
MeSH ID D019343
PubChem ID 311
TTD Drug ID D02RTS
NDC Product Code 81803-040
UNII XF417D3PSL
Synonyms Citric Acid | Citric Acid Monohydrate | Uralyt U | Citrate | Citric Acid, Anhydrous | Anhydrous Citric Acid
Chemical Information
Molecular Formula C6H8O7
CAS Registry Number 77-92-9
SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.199009%
Abdominal pain upper07.01.05.003--
Apathy19.04.04.002--Not Available
Asthenia08.01.01.0010.905673%Not Available
Blood calcium decreased13.11.01.002--Not Available
Chills15.05.03.016; 08.01.09.0010.474384%
Cold sweat23.02.03.002; 08.01.03.0240.001816%Not Available
Confusional state19.13.01.001; 17.02.03.0050.178162%
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.0061.861170%
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.0010.708481%
Dyspepsia07.01.02.0010.494735%
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QRS complex13.14.05.034--Not Available
Electrocardiogram ST segment13.14.05.035--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0091.836733%Not Available
Flat affect19.04.01.004--Not Available
Headache17.14.01.0010.148771%
Hyperhidrosis23.02.03.004; 08.01.03.0281.440532%
Hyperkalaemia14.05.03.001--
Hypoaesthesia23.03.03.081; 17.02.06.0230.037647%Not Available
Hypocalcaemia14.04.01.004--
Hypotension24.06.03.002--
Injection site haematoma12.07.03.004; 08.02.03.004; 24.07.01.0090.168420%Not Available
Liver disorder09.01.08.001--Not Available
Movement disorder17.01.02.0100.010733%Not Available
Muscle spasms15.05.03.0040.050361%
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