Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status approved; investigational
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 42658-010; 12502-5406; 0143-9871; 44087-4000; 54893-0115; 76055-0051; 63323-140; 59605-3006; 65129-1260; 76055-0052; 12502-4912; 58623-0037
UNII 47M74X9YT5
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Inflammation10.02.01.089; 08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.0020.000306%Not Available
Partial seizures17.12.03.0100.000336%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Culture negative13.08.02.001--Not Available
Complication of pregnancy18.02.02.0030.000306%Not Available
Ill-defined disorder08.01.03.0490.000933%Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Lung neoplasm22.08.01.006; 16.19.04.0010.000153%Not Available
Renal impairment20.01.03.010--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Hypophagia07.01.06.010; 19.09.01.004; 14.03.01.0060.000153%Not Available
Breath sounds abnormal13.15.01.008--Not Available
Viral skin infection23.11.05.009; 11.05.04.004--Not Available
Bone marrow failure01.03.03.0050.000306%
Hypertransaminasaemia09.01.02.0050.000229%Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.000780%
Acute kidney injury20.01.03.016--
Fungal test13.08.06.001--Not Available
Functional gastrointestinal disorder07.11.01.016--Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000382%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 10.01.01.021; 23.03.05.0050.000917%Not Available
Autoimmune haemolytic anaemia10.04.01.005; 01.06.01.004--Not Available
Candida infection11.03.03.021--
Respiratory symptom22.12.02.0130.000520%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000229%
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ADReCS-Target
Drug Name ADR Term Target
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