Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status approved; investigational
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 42658-010; 12502-5406; 0143-9871; 44087-4000; 54893-0115; 76055-0051; 63323-140; 59605-3006; 65129-1260; 76055-0052; 12502-4912; 58623-0037
UNII 47M74X9YT5
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Febrile neutropenia08.05.02.004; 01.02.03.0020.000688%
Feeling abnormal08.01.09.0140.001452%Not Available
Feeling hot08.01.09.009--Not Available
Flatulence07.01.04.0020.000596%
Fluid retention20.01.02.003; 14.05.06.0020.000596%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.000596%
Fungal infection11.03.05.001--Not Available
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.0020.001804%
Gastric cancer16.13.03.001; 07.21.02.0010.000153%Not Available
Gastric ulcer07.04.03.0020.000153%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gestational diabetes18.02.04.001; 14.06.01.008; 05.06.01.0080.000153%Not Available
Gingival bleeding07.09.07.001; 24.07.02.0100.000780%Not Available
Glioblastoma17.20.02.002; 16.30.02.0020.000153%Not Available
Graft versus host disease12.02.09.001; 10.02.01.027--Not Available
Groin pain15.03.02.0040.000520%Not Available
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.0010.011466%
Hemiparesis17.01.04.0010.000153%
Hemiplegia17.01.04.0020.000153%Not Available
Hepatic failure09.01.03.002--
Hepatic steatosis14.08.04.005; 09.01.07.0030.000153%Not Available
Hepatitis09.01.07.0040.000229%Not Available
Hepatitis acute09.01.07.0050.000306%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.000229%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000229%Not Available
Herpes virus infection11.05.02.008--Not Available
Herpes zoster23.11.05.005; 17.09.03.026; 11.05.02.003--
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ADReCS-Target
Drug Name ADR Term Target
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