Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status approved; illicit
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 0781-8014; 82348-103; 69238-1305; 72205-047; 72606-003; 0832-0580; 10094-205; 10094-220; 69037-0009; 16729-446; 67877-658; 68180-156; 68180-158; 70710-1325; 70771-1441; 72205-048; 72606-004; 11014-0114; 42571-308; 48087-0117; 16714-888; 62135-527; 67386-315; 67877-665; 69452-116; 67877-666; 0832-0581; 51991-900; 59651-401; 69452-115; 10094-210; 31722-640; 42571-315; 51672-4202; 60687-423; 67386-314; 69238-1535; 69539-154; 65085-0054; 16714-887; 31722-639; 51672-4227; 66689-058; 11014-0115; 68180-157; 69238-1306; 69452-114; 70710-1326; 47621-047; 16729-445; 31722-641; 51672-4203; 0781-8013; 12828-0084; 69766-016; 16714-087; 51672-4210; 67386-313; 69539-153; 70771-1440; 48087-0094; 64330-110; 42571-316; 51991-901; 51991-958
UNII 2MRO291B4U
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abortion spontaneous18.01.04.0010.000457%Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000196%Not Available
Affective disorder19.04.04.0010.000889%Not Available
Aggression19.05.01.0010.008297%Not Available
Agitation19.06.02.001; 17.02.05.0120.002731%
Altered state of consciousness19.07.01.003; 17.02.04.0010.000131%Not Available
Amnesia19.20.01.001; 17.03.02.0010.000353%
Anaemia01.03.02.001--
Anger19.04.02.0010.001398%Not Available
Anterograde amnesia19.20.01.005; 17.03.02.005--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Apnoea22.02.01.0010.000196%
Aspiration22.02.07.0070.000131%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.0040.000732%
Blepharospasm17.17.02.001; 06.05.01.0010.000444%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000327%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bundle branch block right02.03.01.0110.000131%Not Available
Cardiac arrest02.03.04.0010.000523%
Cerebral atrophy17.11.01.0010.000131%Not Available
Coma17.02.09.0010.000588%Not Available
Condition aggravated08.01.03.004--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
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ADReCS-Target
Drug Name ADR Term Target
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