Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status approved; illicit
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 0781-8014; 82348-103; 69238-1305; 72205-047; 72606-003; 0832-0580; 10094-205; 10094-220; 69037-0009; 16729-446; 67877-658; 68180-156; 68180-158; 70710-1325; 70771-1441; 72205-048; 72606-004; 11014-0114; 42571-308; 48087-0117; 16714-888; 62135-527; 67386-315; 67877-665; 69452-116; 67877-666; 0832-0581; 51991-900; 59651-401; 69452-115; 10094-210; 31722-640; 42571-315; 51672-4202; 60687-423; 67386-314; 69238-1535; 69539-154; 65085-0054; 16714-887; 31722-639; 51672-4227; 66689-058; 11014-0115; 68180-157; 69238-1306; 69452-114; 70710-1326; 47621-047; 16729-445; 31722-641; 51672-4203; 0781-8013; 12828-0084; 69766-016; 16714-087; 51672-4210; 67386-313; 69539-153; 70771-1440; 48087-0094; 64330-110; 42571-316; 51991-901; 51991-958
UNII 2MRO291B4U
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary retention20.02.02.0110.000980%
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria10.01.06.001; 23.04.02.001--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.0030.002587%
Weight increased13.15.01.006--
Withdrawal syndrome19.07.06.023; 08.06.02.0120.000666%Not Available
Brain oedema17.07.02.003; 12.01.10.0100.000131%
Brain death17.02.03.003; 08.04.01.0040.000131%Not Available
Balance disorder08.01.03.081; 17.02.02.0070.000418%Not Available
Tonic clonic movements17.12.03.0060.000131%Not Available
Musculoskeletal stiffness15.03.05.027--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Growth retardation15.03.05.016; 14.03.02.031; 05.03.02.0070.000131%
Dysphemia19.19.03.005; 17.02.08.0100.000444%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Drug resistance08.06.01.0050.000131%Not Available
Hepatic enzyme increased13.03.04.028--Not Available
Adverse event08.06.01.0100.002666%Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Motor dysfunction17.01.02.031; 15.05.06.0060.000131%Not Available
Partial seizures17.12.03.0100.000353%Not Available
Abnormal behaviour19.01.01.0010.010166%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Blood disorder01.05.01.004--Not Available
Adverse drug reaction08.06.01.0090.000954%Not Available
Drug intolerance08.06.01.0130.001019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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