Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clonidine hydrochloride
Drug ID BADD_D00503
Description Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Indications and Usage Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Marketing Status approved
ATC Code C02AC01; S01EA04; N02CX02
DrugBank ID DB00575
KEGG ID D00604
MeSH ID D003000
PubChem ID 20179
TTD Drug ID D03SKR
NDC Product Code 43063-924; 50268-194; 51655-962; 0228-2127; 55154-2577; 59651-232; 62332-055; 63629-2319; 68788-7145; 70934-851; 71034-001; 76420-286; 43547-435; 50090-5089; 52817-180; 61919-268; 63187-419; 68001-568; 68071-2631; 70518-3350; 70771-1194; 71205-570; 71335-0777; 71335-0922; 71610-449; 76420-283; 68981-029; 43063-817; 43547-566; 43547-567; 50268-193; 53002-4140; 63629-2316; 63629-2317; 68001-237; 70518-1959; 70771-1193; 71335-0539; 71335-1495; 59212-658; 60687-462; 62332-054; 63629-1208; 63629-2315; 67296-1196; 68382-601; 68788-8080; 70518-3162; 71205-218; 71205-588; 71335-9682; 52935-0051; 0143-9723; 50090-5105; 0228-2128; 68001-238; 68180-606; 70518-3295; 38779-0561; 29300-135; 29300-137; 29300-468; 51655-445; 0228-2129; 58657-649; 60760-057; 62332-056; 68071-2210; 70934-671; 71335-0121; 72789-091; 42413-0053; 53747-010; 45865-797; 46708-308; 50090-1910; 50268-192; 0228-4241; 60687-113; 60687-124; 70518-0898; 70518-2203; 0615-2572; 0615-2574; 0615-8272; 76420-285; 42291-148; 50090-5577; 51655-570; 53002-4141; 55154-2576; 55700-704; 59651-234; 61919-267; 61919-718; 63629-2314; 68001-239; 68071-4041; 68382-602; 70518-1000; 70518-1811; 76420-066; 29300-136; 43353-316; 0143-9724; 46708-306; 50090-4360; 50090-5103; 51655-353; 55700-802; 59651-233; 63629-2318; 63629-7652; 63629-9269; 67296-0685; 67457-218; 70518-3276; 51927-2379; 79572-009; 81371-7005; 27241-108; 43547-565; 51655-451; 52817-182; 53002-4940; 53002-4941; 58657-648; 61919-605; 68071-2699; 68788-8163; 70518-1962; 71335-0050; 71335-0915; 71335-1624; 49452-2147; 62991-1422; 43063-925; 46708-307; 52817-181; 58118-0072; 58657-647
UNII W76I6XXF06
Synonyms Clonidine | Klofenil | Clofenil | Chlophazolin | Clonidine Dihydrochloride | Dihydrochloride, Clonidine | Clonidine Hydrochloride | Hydrochloride, Clonidine | Clonidine Monohydrochloride | Monohydrochloride, Clonidine | Clonidine Monohydrobromide | Monohydrobromide, Clonidine | ST-155 | ST 155 | ST155 | Gemiton | Hemiton | Isoglaucon | Klofelin | Clofelin | Clopheline | M-5041T | M 5041T | M5041T | Catapres | Catapresan | Catapressan | Dixarit
Chemical Information
Molecular Formula C9H10Cl3N3
CAS Registry Number 4205-91-8
SMILES C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nocturia20.02.03.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Pallor23.03.03.031; 08.01.03.032; 24.03.04.001--Not Available
Palpitations02.11.04.012--
Paraesthesia23.03.03.094; 17.02.06.005--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Parotitis11.01.04.001; 07.06.04.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Restlessness17.02.05.021; 19.11.02.002--
Rhinitis22.07.03.006; 11.01.13.004--
Sedation17.02.04.005--Not Available
Sexual dysfunction21.03.02.003; 19.08.05.002--Not Available
Sinus bradycardia02.03.03.009--
Skin irritation23.03.04.009--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.10.013--Not Available
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