Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal hypermotility07.02.04.0050.001223%Not Available
Foetor hepaticus09.01.05.006; 07.01.06.026--Not Available
Coronary artery insufficiency24.04.04.016; 02.02.01.008--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Organ failure08.01.03.0410.006726%Not Available
Alcohol withdrawal syndrome19.07.06.005; 08.06.02.0020.003057%Not Available
Delusional disorder, persecutory type19.03.03.0010.003057%Not Available
Abdominal strangulated hernia24.04.08.013; 07.16.06.0040.001223%Not Available
Cardiac discomfort02.11.04.0010.001223%Not Available
Myoclonic epilepsy17.12.03.007--Not Available
Dysphemia19.19.03.005; 17.02.08.0100.015408%Not Available
Brain cancer metastatic17.20.04.001; 16.30.04.0010.001223%Not Available
Hepatic cancer metastatic16.07.02.002; 09.04.02.0060.001223%Not Available
Parkinsonian gait17.01.05.005; 08.01.02.0050.001223%Not Available
Fluid intake reduced14.05.10.0010.004280%Not Available
Faecaloma07.01.03.0040.035463%Not Available
Pre-existing disease08.01.03.0590.001223%Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Alcoholic pancreatitis07.18.01.0050.003057%Not Available
Colitis microscopic07.08.01.011--Not Available
Faecalith07.01.03.0070.001223%Not Available
Impaired fasting glucose14.06.02.004; 05.06.02.0040.001223%Not Available
Pneumatosis intestinalis07.11.01.043--Not Available
Testis cancer21.13.02.001; 16.25.03.0010.008560%Not Available
Chronic inflammatory demyelinating polyradiculoneuropathy17.09.04.004; 10.04.10.0040.001834%Not Available
Bipolar disorder19.16.01.0030.039132%Not Available
Cognitive disorder19.21.02.001; 17.03.03.003--
Vascular dementia17.03.01.003; 24.04.06.017; 19.20.04.0010.002446%Not Available
Major depression19.15.01.0030.013452%Not Available
Metabolic disorder14.11.01.0010.012473%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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