Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyslipidaemia14.08.04.015--Not Available
Pulseless electrical activity02.03.04.020--Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.144910%Not Available
Serositis08.01.05.0060.001834%Not Available
Hypoperfusion24.06.02.0190.001223%Not Available
Intestinal mass07.11.01.0100.001223%Not Available
Ventricular dysfunction02.04.02.0050.005503%Not Available
Infrequent bowel movements07.02.02.0110.005503%Not Available
Angiopathy24.03.02.0070.006114%Not Available
Metastases to central nervous system17.02.10.013; 16.22.02.004--Not Available
Adhesion08.01.03.0480.001223%Not Available
Hepatic enzyme increased13.03.04.028--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Neurological symptom17.02.05.010--Not Available
Freezing phenomenon17.01.05.0060.014308%Not Available
Adverse event08.06.01.010--Not Available
Benign neoplasm16.02.02.0070.001223%Not Available
Brain neoplasm17.20.01.003; 16.30.01.0030.026903%Not Available
Cardiac disorder02.11.01.0030.129135%Not Available
Diabetic complication05.07.03.002; 14.07.03.0020.004280%Not Available
Electrocardiogram change13.14.05.014--Not Available
Eye movement disorder17.02.05.025; 06.05.02.0080.006114%Not Available
Eyelid disorder23.03.03.028; 06.08.03.010--Not Available
Embolism24.01.01.009--
Gastrointestinal motility disorder07.02.03.001--Not Available
Infarction24.04.02.017--Not Available
Ischaemia24.04.02.0040.004891%Not Available
Malnutrition14.03.02.0040.013696%Not Available
Mental disorder19.07.01.0020.261204%Not Available
Metastatic neoplasm16.16.01.0070.011617%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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