Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oromandibular dystonia17.01.03.006--Not Available
Brain injury17.11.01.003; 19.07.03.0070.018954%Not Available
Cholestatic liver injury09.01.07.016--Not Available
Traumatic liver injury12.01.17.027; 09.01.08.010--Not Available
Intellectual disability19.21.06.001; 17.03.07.0010.011617%Not Available
Hypertransaminasaemia09.01.02.005--Not Available
Oropharyngeal discomfort22.12.03.015; 07.05.05.008--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.004--
Anosognosia19.21.01.004; 17.02.03.0100.012840%Not Available
Acute kidney injury20.01.03.016--
Langerhans' cell histiocytosis16.21.04.003; 15.09.03.008; 01.13.04.003; 09.01.08.018; 22.01.01.0160.001834%Not Available
Toxicity to various agents12.03.01.046--Not Available
Allergic hepatitis10.01.03.038; 09.01.07.0270.001223%Not Available
Functional gastrointestinal disorder07.11.01.0160.004891%Not Available
Slow speech19.19.02.004; 17.02.08.016--Not Available
Substance-induced psychotic disorder19.03.01.007; 12.03.01.053--Not Available
Hepatic cancer16.07.02.004; 09.04.02.008--Not Available
Rebound psychosis08.06.02.016; 19.03.01.0060.007337%Not Available
Respiratory symptom22.12.02.0130.005136%Not Available
Intrusive thoughts19.10.03.0080.001223%Not Available
Multiple organ dysfunction syndrome08.01.03.057--
Myeloproliferative neoplasm16.21.03.006; 01.13.03.0060.002446%Not Available
Anal incontinence17.05.01.021; 07.01.06.0290.010639%
Depersonalisation/derealisation disorder19.14.01.0040.001834%Not Available
Somatic symptom disorder19.24.01.0060.001223%Not Available
Illness anxiety disorder19.24.01.0020.001834%Not Available
Acoustic neuroma16.09.02.002; 04.04.04.003; 17.18.02.0020.001223%Not Available
Adenocarcinoma of colon16.13.01.010; 07.21.01.0080.001834%Not Available
Alcoholic liver disease09.01.07.0310.001834%Not Available
Anorexia nervosa19.09.01.007; 14.03.03.0020.001223%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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