ADReCS

Pharmaceutical Information

Drug Name	Clozapine
Drug ID	BADD_D00511
Description	A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage	For use in patients with treatment-resistant schizophrenia.
Marketing Status	approved
ATC Code	N05AH02
DrugBank ID	DB00363
KEGG ID	D00283
MeSH ID	D003024
PubChem ID	135398737
TTD Drug ID	D0Z1RV
NDC Product Code	73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII	J60AR2IKIC
Synonyms	Clozapine \| Clozaril \| Leponex

Chemical Information

Molecular Formula	C18H19ClN4
CAS Registry Number	5786-21-0
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Atonic seizures	17.12.03.020	0.001834%		Not Available
B precursor type acute leukaemia	16.01.01.004; 01.10.01.004	0.001223%		Not Available
Bone cancer	15.09.03.012; 16.29.02.002	0.002446%		Not Available
Borderline personality disorder	19.05.03.003	0.004280%		Not Available
Brain neoplasm malignant	17.20.04.002; 16.30.04.002	0.002446%		Not Available
Breast cancer stage III	16.10.01.012; 21.05.01.020	0.001834%		Not Available
Bronchial carcinoma	22.08.01.015; 16.19.02.004	-	-	Not Available
Central nervous system lymphoma	01.12.01.005; 18.04.04.013; 17.02.10.028; 16.20.01.005	0.001223%		Not Available
Drowning	12.01.18.003; 08.04.01.014	0.007337%		Not Available
Fear of disease	19.06.03.007	0.001834%		Not Available
Grandiosity	19.05.01.019	0.001223%		Not Available
Grief reaction	19.23.01.003	-	-	Not Available
Head banging	19.11.03.007	0.001834%		Not Available
Large granular lymphocytosis	16.01.11.001; 01.10.11.001	0.001834%		Not Available
Lung adenocarcinoma	22.08.01.007; 16.19.01.002	-	-	Not Available
Lung carcinoma cell type unspecified recurrent	22.08.01.018; 16.19.02.005	0.001834%		Not Available
Lung carcinoma cell type unspecified stage IV	22.08.01.019; 16.19.02.006	0.006114%		Not Available
Macrosomia	08.01.03.073	0.001834%		Not Available
Metastases to kidney	16.22.02.017; 20.01.04.010	0.001223%		Not Available
Metastases to lymph nodes	16.22.02.006; 01.09.01.015	-	-	Not Available
Monocytopenia	01.02.02.005	0.002446%		Not Available
Myocardial fibrosis	02.04.02.016	0.001223%		Not Available
Neglect of personal appearance	19.01.02.015	0.001834%		Not Available
Nephritis allergic	10.01.03.044; 20.05.01.018	0.001223%		Not Available
Normal newborn	18.08.06.001	-	-	Not Available
Nucleated red cells	01.07.02.012	-	-	Not Available
Obstruction gastric	07.13.04.002	0.001223%
Oropharyngeal cancer	16.19.05.003; 07.21.07.004; 22.08.02.004	0.001223%		Not Available
Overweight	14.03.02.021	0.012229%		Not Available
Panniculitis lobular	23.07.02.005	0.001223%		Not Available

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