Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Foaming at mouth17.02.05.056; 08.01.03.070; 07.05.05.019--Not Available
Acute left ventricular failure02.05.02.0050.001223%Not Available
Metastatic squamous cell carcinoma16.16.01.0100.001834%Not Available
Accidental death12.01.08.040; 08.04.01.0130.003669%Not Available
Multimorbidity08.01.03.0750.001834%Not Available
Faecal vomiting07.01.07.0130.002446%Not Available
Tachyphrenia19.10.03.010; 17.03.03.0070.002446%Not Available
Volvulus of small bowel07.13.06.0100.002446%Not Available
Weight bearing difficulty15.03.05.0340.001223%Not Available
Stomach mass07.11.01.0300.001223%Not Available
Right atrial dilatation02.04.02.0320.003669%Not Available
Left atrial dilatation02.04.02.0250.008805%Not Available
Apparent death08.01.03.0620.002446%Not Available
Tobacco interaction08.06.03.0070.011617%Not Available
Schizoaffective disorder bipolar type19.03.02.0030.006726%Not Available
Respiratory tract inflammation22.02.07.0150.001223%Not Available
Frontotemporal dementia19.20.02.008; 17.03.01.0070.001834%Not Available
Decreased eye contact19.01.02.012; 17.02.05.0550.001834%Not Available
Seizure like phenomena17.12.03.0300.003057%Not Available
Systolic dysfunction02.04.02.0350.004891%Not Available
Encephalitis autoimmune16.32.01.006; 10.04.10.012; 17.06.05.0020.001834%Not Available
Benign ethnic neutropenia01.02.03.0140.022256%Not Available
End stage renal disease20.01.03.019--Not Available
Intracranial mass17.11.01.0170.001834%Not Available
Obsessive-compulsive symptom19.06.05.0100.002446%Not Available
Selective eating disorder19.09.01.012; 14.03.02.0240.003669%Not Available
Acute cardiac event02.11.01.0010.001223%Not Available
Alcohol use disorder19.07.06.0040.002446%Not Available
Baseline foetal heart rate variability disorder18.03.02.019; 02.03.02.0310.001834%Not Available
Behaviour disorder19.01.01.0050.015286%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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