| Pharmaceutical Information |
| Drug Name |
Clozapine |
| Drug ID |
BADD_D00511 |
| Description |
A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
| Indications and Usage |
For use in patients with treatment-resistant schizophrenia. |
| Marketing Status |
approved |
| ATC Code |
N05AH02 |
| DrugBank ID |
DB00363
|
| KEGG ID |
D00283
|
| MeSH ID |
D003024
|
| PubChem ID |
135398737
|
| TTD Drug ID |
D0Z1RV
|
| NDC Product Code |
73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903 |
| UNII |
J60AR2IKIC
|
| Synonyms |
Clozapine | Clozaril | Leponex |
|
| Chemical Information |
| Molecular Formula |
C18H19ClN4 |
| CAS Registry Number |
5786-21-0 |
| SMILES |
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42 |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
| Vein collapse | 24.03.02.039; 12.02.01.040 | 0.001223% | | Not Available | | Withdrawal catatonia | 19.11.01.004; 08.06.02.028 | 0.011617% | | Not Available | | Internal hernia | 07.16.06.001 | - | - | Not Available |
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