Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Codeine
Drug ID BADD_D00516
Description The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, _Papaver somniferum_ (Papaveraceae).[A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.[LABEL,A175096]
Indications and Usage Codeine sulfate is a form of this drug that is commonly used. It is available in tablet form [FDA label] and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate [FDA label]. The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above [L5521], [L5524].
Marketing Status approved; illicit
ATC Code R05DA04
DrugBank ID DB00318
KEGG ID D00195; D02101
MeSH ID D003061
PubChem ID 5284371
TTD Drug ID D03DIG
NDC Product Code 10191-1035; 10191-1038; 10191-1033; 10191-1036; 10191-1034; 10191-1037
UNII Q830PW7520
Synonyms Codeine | Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- | N-Methylmorphine | N Methylmorphine | Isocodeine | Codeine Phosphate | Ardinex
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 76-57-3
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sluggishness08.01.01.0040.000343%Not Available
Small intestinal obstruction07.13.06.0010.000686%
Sneezing22.12.03.024--
Somnolence19.02.05.003; 17.02.04.0060.008031%
Stupor17.02.04.007; 19.02.05.0040.000515%Not Available
Suicide attempt19.12.01.0040.002059%
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.0070.002128%Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.000515%Not Available
Tremor17.01.06.002--
Unresponsive to stimuli17.02.05.0310.001613%Not Available
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.0110.000515%
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.0010.007516%
Vertigo04.04.01.003; 17.02.12.002--
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.0030.028656%
Withdrawal syndrome19.07.06.023; 08.06.02.0120.002059%Not Available
Xerosis08.01.03.0160.000343%Not Available
Yawning22.12.03.037--Not Available
Mobility decreased15.03.05.023; 17.02.05.018; 08.01.03.0300.000755%Not Available
Hypoacusis04.02.01.0060.000927%
Brain oedema17.07.02.003; 12.01.10.0100.000755%
Balance disorder08.01.03.081; 17.02.02.0070.001030%Not Available
Bile duct stenosis09.02.02.0010.000343%
Conjunctival hyperaemia06.04.01.0040.000343%Not Available
Ureteral spasm20.06.01.002--Not Available
Musculoskeletal discomfort15.03.04.0010.000515%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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