| Drug Name |
Collagenase clostridium histolyticum |
| Drug ID |
BADD_D00525 |
| Description |
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease.[L14882] The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers.[L14912]
On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA for the treatment of cellulite in adult women.[L14872] Also known as Qwo, this injection is the first approved injectable treatment for cellulite and was developed by Endo International.[L14892] |
| Indications and Usage |
Collagenase clostridium histolyticum is indicated for the treatment of adults with Dupuytren's contracture with a palpable cord. Additionally, it is used to treat men with Peyronie's disease diagnosed with a penile curvature deformity of at least a 30-degree angle at the beginning of therapy in addition to palpable plaques.[L14882] Collagenase ointment is used for the tissue debridement of chronic dermal ulcers and severely burned tissues.[L14952]
The combination collagenase product, also known as Qwo, is used for the treatment of moderate to severe cellulite in the buttocks of adult women.[L14872] |
| Marketing Status |
approved; investigational |
| ATC Code |
M09AB02 |
| DrugBank ID |
DB00048
|
| KEGG ID |
D09596
|
| MeSH ID |
D003012
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D0I4ZQ
|
| NDC Product Code |
66887-003; 65044-7466 |
| UNII |
9X7O8V25IT
|
| Synonyms |
Microbial Collagenase | Clostridium histolyticum Collagenase | Collagenase, Clostridium histolyticum | Nucleolysin | Collagenase, Microbial | Collalysine | Clostridiopeptidase A | Collagenase Clostridium histolyticum | Clostridium histolyticum, Collagenase | histolyticum, Collagenase Clostridium | Collagenase-Like Peptidase | Collagenase Like Peptidase | Peptidase, Collagenase-Like |
