Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Corticotropin
Drug ID BADD_D00531
Description Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Indications and Usage For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. Purified corticotropin for injection is indicated for a variety of allergic and autoimmune conditions.[L39150]
Marketing Status approved; investigational; vet_approved
ATC Code H01AA01
DrugBank ID DB01285
KEGG ID D00146
MeSH ID D000324
PubChem ID 16132265
TTD Drug ID D0R4HQ
NDC Product Code 51552-1613; 59149-005; 61200-004; 38779-1904; 63474-200
UNII K0U68Q2TXA
Synonyms Adrenocorticotropic Hormone | Hormone, Adrenocorticotropic | ACTH (1-39) | ACTH | Corticotrophin | Corticotropin | Corticotropin (1-39) | Corticotrophin (1-39) | Adrenocorticotrophic Hormone | Hormone, Adrenocorticotrophic | 1-39 ACTH | Adrenocorticotropin
Chemical Information
Molecular Formula C207H308N56O58S
CAS Registry Number 9002-60-2
SMILES CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC= CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(C C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5 =CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC (=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O) C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C (CC1=CC=CC=C1)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O) C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Alkalosis hypokalaemic14.01.02.002--Not Available
Body temperature increased13.15.01.001--Not Available
Brain compression17.07.02.005--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.017--Not Available
Constipation07.02.02.001--
Cushingoid24.08.02.004; 19.07.03.001; 14.11.01.006; 05.01.01.002--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema23.03.06.001--Not Available
Exophthalmos05.02.02.002; 06.09.04.001--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Headache17.14.01.001--
Hirsutism05.05.01.005; 23.02.04.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Impaired healing08.03.02.001--Not Available
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Infection11.01.08.002--Not Available
Intracranial pressure increased17.07.02.002--Not Available
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