Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Corticotropin
Drug ID BADD_D00531
Description Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Indications and Usage For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. Purified corticotropin for injection is indicated for a variety of allergic and autoimmune conditions.[L39150]
Marketing Status approved; investigational; vet_approved
ATC Code H01AA01
DrugBank ID DB01285
KEGG ID D00146
MeSH ID D000324
PubChem ID 16132265
TTD Drug ID D0R4HQ
NDC Product Code 51552-1613; 59149-005; 61200-004; 38779-1904; 63474-200
UNII K0U68Q2TXA
Synonyms Adrenocorticotropic Hormone | Hormone, Adrenocorticotropic | ACTH (1-39) | ACTH | Corticotrophin | Corticotropin | Corticotropin (1-39) | Corticotrophin (1-39) | Adrenocorticotrophic Hormone | Hormone, Adrenocorticotrophic | 1-39 ACTH | Adrenocorticotropin
Chemical Information
Molecular Formula C207H308N56O58S
CAS Registry Number 9002-60-2
SMILES CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC= CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(C C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5 =CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC (=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O) C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C (CC1=CC=CC=C1)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O) C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability19.04.02.013; 08.01.03.011--
Menstruation irregular21.01.01.005; 05.05.01.008--
Mood swings19.04.03.001--Not Available
Muscle disorder15.05.03.014--Not Available
Muscular weakness15.05.06.001; 17.05.03.005--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Optic neuritis17.04.05.001; 06.04.08.002; 10.02.01.097--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Pancreatitis07.18.01.001--
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Skin atrophy23.01.05.001--
Skin disorder23.03.03.007--Not Available
Spinal compression fracture15.08.05.004; 14.04.04.003; 12.04.04.001--Not Available
Subdural haematoma24.07.04.005; 17.08.05.002; 12.01.10.003--Not Available
Vasculitis necrotising10.02.02.008; 24.12.04.029--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Oesophagitis ulcerative07.04.05.003--Not Available
Affect lability19.04.01.001--Not Available
Subdural effusion17.02.10.010--Not Available
Muscle mass15.05.03.018--Not Available
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