Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyclizine
Drug ID BADD_D00543
Description A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Indications and Usage For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
Marketing Status approved
ATC Code R06AE03
DrugBank ID DB01176
KEGG ID D03621
MeSH ID D003501
PubChem ID 6726
TTD Drug ID D08HRJ
NDC Product Code Not Available
UNII QRW9FCR9P2
Synonyms Cyclizine | Marezine | Cyclizine Hydrochloride | Hydrochloride, Cyclizine | Cyclizine HCl | HCl, Cyclizine
Chemical Information
Molecular Formula C18H22N2
CAS Registry Number 82-92-8
SMILES CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Apnoea22.02.01.001--
Asthenia08.01.01.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Chills15.05.03.016; 08.01.09.001--
Chorea17.01.01.001--Not Available
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Dermatitis bullous23.03.01.002--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Drug eruption10.01.01.005; 08.01.06.015; 23.03.05.001--Not Available
Dyskinesia17.01.02.006--
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Hallucinations, mixed19.10.04.008--Not Available
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Injection site reaction12.07.03.015; 08.02.03.014--
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