Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cyproheptadine hydrochloride
Drug ID BADD_D00553
Description Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.[A231274]
Indications and Usage In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with epinephrine.[L32474] In Canada, cyproheptadine is available over-the-counter and is indicated for the treatment of pruritus and for appetite stimulation.[L32519] In Australia, cyproheptadine is additionally indicated for the treatment vascular headaches.[L32479] Cyproheptadine is also used off-label for the treatment of serotonin syndrome.[A231274]
Marketing Status approved
ATC Code R06AX02
DrugBank ID DB00434
KEGG ID D02234
MeSH ID D003533
PubChem ID 13770
TTD Drug ID D00TLN
NDC Product Code 50268-189; 51407-272; 64980-504; 17337-0508; 71554-003; 62135-236; 70518-2414; 70518-3517; 70752-101; 71335-1859; 66689-333; 71205-989; 66577-040; 27808-099; 46438-0036; 10135-638; 64380-795; 70710-1110; 70752-107; 71205-024; 49452-2409; 52817-210; 69367-246; 76385-130; 38779-1226; 42708-156; 50090-6129; 51991-838; 62991-1232; 16571-805; 23155-703; 42708-177; 62135-949; 39328-544; 50742-190; 63629-2062; 0527-1949; 70771-1076; 71335-1107; 72789-102; 66577-014; 0115-1757
UNII NJ82J0F8QC
Synonyms Cyproheptadine | Dihexazin | Peritol | Viternum | Antergan | Periactin
Chemical Information
Molecular Formula C21H22ClN
CAS Registry Number 969-33-5
SMILES CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholestasis09.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Conversion disorder19.24.01.001--Not Available
Coordination abnormal17.02.02.004--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dry throat07.06.01.005; 22.12.03.005--Not Available
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Euphoric mood19.04.02.006--
Extrasystoles02.03.02.003--Not Available
Fatigue08.01.01.002--
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002--
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