| Pharmaceutical Information |
| Drug Name |
Cyproheptadine hydrochloride |
| Drug ID |
BADD_D00553 |
| Description |
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.[A231274] |
| Indications and Usage |
In the US, prescription cyproheptadine is indicated for the treatment of various allergic symptomatologies - including dermatographia, rhinitis, conjunctivitis, and urticaria - as well as adjunctive therapy in the management of anaphylaxis following treatment with epinephrine.[L32474] In Canada, cyproheptadine is available over-the-counter and is indicated for the treatment of pruritus and for appetite stimulation.[L32519] In Australia, cyproheptadine is additionally indicated for the treatment vascular headaches.[L32479]
Cyproheptadine is also used off-label for the treatment of serotonin syndrome.[A231274] |
| Marketing Status |
approved |
| ATC Code |
R06AX02 |
| DrugBank ID |
DB00434
|
| KEGG ID |
D02234
|
| MeSH ID |
D003533
|
| PubChem ID |
13770
|
| TTD Drug ID |
D00TLN
|
| NDC Product Code |
50268-189; 51407-272; 64980-504; 17337-0508; 71554-003; 62135-236; 70518-2414; 70518-3517; 70752-101; 71335-1859; 66689-333; 71205-989; 66577-040; 27808-099; 46438-0036; 10135-638; 64380-795; 70710-1110; 70752-107; 71205-024; 49452-2409; 52817-210; 69367-246; 76385-130; 38779-1226; 42708-156; 50090-6129; 51991-838; 62991-1232; 16571-805; 23155-703; 42708-177; 62135-949; 39328-544; 50742-190; 63629-2062; 0527-1949; 70771-1076; 71335-1107; 72789-102; 66577-014; 0115-1757 |
| UNII |
NJ82J0F8QC
|
| Synonyms |
Cyproheptadine | Dihexazin | Peritol | Viternum | Antergan | Periactin |
|
| Chemical Information |
| Molecular Formula |
C21H22ClN |
| CAS Registry Number |
969-33-5 |
| SMILES |
CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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