Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyproterone acetate
Drug ID BADD_D00555
Description An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Indications and Usage For the palliative treatment of patients with advanced prostatic carcinoma.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB04839
KEGG ID D01368
MeSH ID D017373
PubChem ID 9880
TTD Drug ID Not Available
NDC Product Code 53104-7635; 46439-8720; 59010-000
UNII 4KM2BN5JHF
Synonyms Cyproterone Acetate | Cyproterone Acetate, (17 alpha)-Isomer | Cyproterone Acetate, (1 alpha,2 alpha,9 beta,10 alpha)-Isomer | Androcur | Cyproterone Acetate, (1 alpha,2 alpha)-Isomer
Chemical Information
Molecular Formula C24H29ClO4
CAS Registry Number 427-51-0
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Accommodation disorder06.02.04.001--Not Available
Acne23.02.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anovulatory cycle05.05.01.017; 21.01.01.011--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrophy08.03.04.001--Not Available
Azoospermia21.03.03.001--
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness06.02.10.003; 17.17.01.003--Not Available
Blood creatinine increased13.13.01.004--
Body temperature increased13.15.01.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast pain21.05.05.003--
Breast tenderness21.05.05.004--Not Available
Cardiac failure02.05.01.001--
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chills15.05.03.016; 08.01.09.001--
Coma17.02.09.001--Not Available
Coma hepatic17.02.09.002; 09.01.03.005--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
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