Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Deferasirox
Drug ID BADD_D00594
Description Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Indications and Usage For the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Marketing Status approved; investigational
ATC Code V03AC03
DrugBank ID DB01609
KEGG ID D03669
MeSH ID D000077588
PubChem ID 214348
TTD Drug ID D0Q5UQ
NDC Product Code 49706-2103; 59285-010; 66039-871; 31722-030; 43598-852; 45963-454; 45963-456; 67877-552; 69238-1703; 69452-161; 69539-200; 70700-271; 70771-1410; 70771-1471; 58032-2017; 0078-0468; 0078-0469; 31722-013; 43598-854; 69238-1488; 69452-159; 69539-023; 46708-410; 57664-768; 62332-324; 62756-568; 69539-021; 69539-073; 69539-199; 62332-412; 67877-550; 67877-553; 69097-391; 69097-560; 69539-022; 70771-1472; 65727-037; 0078-0655; 42806-371; 43598-851; 67877-554; 68462-495; 68462-496; 69097-392; 70710-1012; 62512-0078; 0078-0470; 0078-0654; 0078-0720; 31722-029; 43598-856; 46708-411; 46708-412; 69097-393; 69238-1486; 69539-303; 70710-1276; 72205-176; 14501-0049; 63278-1070; 65085-0063; 66022-0301; 0078-0656; 31722-031; 43598-855; 57664-769; 62332-325; 62756-569; 69539-075; 70710-1011; 72205-075; 72647-372; 74436-0323; 31722-012; 43598-853; 62332-326; 62332-411; 62756-570; 68462-494; 69097-570; 69238-1487; 69238-1702; 69238-1704; 70710-1013; 70771-1411; 70771-1473; 0591-3853; 72647-371; 0591-2961; 11722-040; 53104-7713; 59651-419; 0078-0727; 42806-372; 46708-324; 46708-325; 57664-770; 67877-549; 69539-074; 70700-270; 72205-076; 65015-738; 0078-0713; 31722-011; 42806-373; 45963-455; 46708-326; 62332-410; 67877-551; 69097-550; 69452-160; 70700-269; 70710-1275; 70710-1277; 70771-1409; 72647-373; 65372-1164
UNII V8G4MOF2V9
Synonyms Deferasirox | 4-(3,5-Bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid | ICL 670A | ICL-670A | ICL670A | ICL-670 | ICL670 | ICL 670 | Exjade
Chemical Information
Molecular Formula C21H15N3O4
CAS Registry Number 201530-41-8
SMILES C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Epigastric discomfort07.01.02.0040.011152%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Organ failure08.01.03.0410.001239%Not Available
Vascular occlusion24.04.02.0150.005452%Not Available
Growth retardation14.03.02.031; 05.03.02.007; 15.03.05.0160.001859%
Nodule08.03.05.0020.001239%Not Available
Transaminases increased13.03.04.036--Not Available
Cerebral disorder17.02.10.0170.004213%Not Available
Haemorrhage24.07.01.0020.019206%Not Available
Fluid intake reduced14.05.10.0010.001239%Not Available
Rectal tenesmus15.05.03.011; 07.03.03.0010.001239%Not Available
Urine odour abnormal20.02.01.0200.001859%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.006319%Not Available
Paraesthesia oral17.02.06.008; 07.05.05.0350.006939%Not Available
Metabolic disorder14.11.01.0010.003346%Not Available
Ocular icterus09.01.01.007; 01.06.04.007; 06.08.03.0090.005824%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.001--Not Available
Gastrointestinal toxicity12.03.01.019; 07.08.03.0060.003346%Not Available
Infrequent bowel movements07.02.02.011--Not Available
Intestinal haemorrhage24.07.02.031; 07.12.03.0050.001859%Not Available
Abdominal symptom07.01.06.0070.003346%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.001239%Not Available
Bladder disorder20.03.01.0020.001859%Not Available
Cardiac disorder02.11.01.0030.017967%Not Available
Feeding disorder14.03.02.003; 19.09.01.0030.002478%Not Available
Inflammation10.02.01.089; 08.01.05.0070.005576%Not Available
Intra-abdominal haemorrhage12.01.17.011; 24.07.02.035; 07.12.02.0080.001239%
Ischaemia24.04.02.0040.001239%Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
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