Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Deferasirox
Drug ID BADD_D00594
Description Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Indications and Usage For the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Marketing Status approved; investigational
ATC Code V03AC03
DrugBank ID DB01609
KEGG ID D03669
MeSH ID D000077588
PubChem ID 214348
TTD Drug ID D0Q5UQ
NDC Product Code 49706-2103; 59285-010; 66039-871; 31722-030; 43598-852; 45963-454; 45963-456; 67877-552; 69238-1703; 69452-161; 69539-200; 70700-271; 70771-1410; 70771-1471; 58032-2017; 0078-0468; 0078-0469; 31722-013; 43598-854; 69238-1488; 69452-159; 69539-023; 46708-410; 57664-768; 62332-324; 62756-568; 69539-021; 69539-073; 69539-199; 62332-412; 67877-550; 67877-553; 69097-391; 69097-560; 69539-022; 70771-1472; 65727-037; 0078-0655; 42806-371; 43598-851; 67877-554; 68462-495; 68462-496; 69097-392; 70710-1012; 62512-0078; 0078-0470; 0078-0654; 0078-0720; 31722-029; 43598-856; 46708-411; 46708-412; 69097-393; 69238-1486; 69539-303; 70710-1276; 72205-176; 14501-0049; 63278-1070; 65085-0063; 66022-0301; 0078-0656; 31722-031; 43598-855; 57664-769; 62332-325; 62756-569; 69539-075; 70710-1011; 72205-075; 72647-372; 74436-0323; 31722-012; 43598-853; 62332-326; 62332-411; 62756-570; 68462-494; 69097-570; 69238-1487; 69238-1702; 69238-1704; 70710-1013; 70771-1411; 70771-1473; 0591-3853; 72647-371; 0591-2961; 11722-040; 53104-7713; 59651-419; 0078-0727; 42806-372; 46708-324; 46708-325; 57664-770; 67877-549; 69539-074; 70700-270; 72205-076; 65015-738; 0078-0713; 31722-011; 42806-373; 45963-455; 46708-326; 62332-410; 67877-551; 69097-550; 69452-160; 70700-269; 70710-1275; 70710-1277; 70771-1409; 72647-373; 65372-1164
UNII V8G4MOF2V9
Synonyms Deferasirox | 4-(3,5-Bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid | ICL 670A | ICL-670A | ICL670A | ICL-670 | ICL670 | ICL 670 | Exjade
Chemical Information
Molecular Formula C21H15N3O4
CAS Registry Number 201530-41-8
SMILES C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema multiforme23.03.01.003; 10.01.03.0150.003098%
Eye disorder06.08.03.001--Not Available
Eye haemorrhage12.02.02.012; 24.07.05.002; 06.07.02.0010.002726%Not Available
Faeces discoloured07.01.03.0020.027756%Not Available
Faeces hard07.01.03.0030.001239%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.003346%Not Available
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.001--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.007435%
Feeling abnormal08.01.09.014--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.005824%
Flatulence07.01.04.0020.006443%
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Frequent bowel movements07.02.04.0020.005452%Not Available
Gallbladder disorder09.03.02.0010.002478%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.003717%
Gastric perforation12.02.03.007; 07.04.03.0010.001859%
Gastric ulcer07.04.03.0020.008054%
Gastritis07.08.02.0010.007683%
Gastritis erosive07.04.03.0030.001859%Not Available
Gastritis haemorrhagic24.07.02.008; 07.08.02.0020.001239%Not Available
Gastrointestinal disorder07.11.01.0010.063815%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.022924%Not Available
Gastrointestinal pain07.01.05.0050.004585%
Gastrointestinal perforation07.04.04.0010.001859%Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.003717%
Gingival pain07.09.13.0100.001239%
Glaucoma06.03.01.0020.001859%
Glycosuria20.02.01.0050.011152%
Graft versus host disease12.02.09.001; 10.02.01.0270.006196%Not Available
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