| Pharmaceutical Information |
| Drug Name |
Delamanid |
| Drug ID |
BADD_D00602 |
| Description |
Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall [A31965]. It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen. Emergence of multidrug-resistant and extensively drug-resistant tuberculosis creates clinical challenges for patients, as the disease is associated with a higher mortality rate and insufficient therapeutic response to standardized antituberculosis treatments as [DB00951] and [DB01045]. Multidrug-resistant tuberculosis may also require more than 2 years of chemotherapy and second-line therapies with narrow therapeutic index [A31968]. In a clinical study involving patients with pulmonary multidrug-resistant tuberculosis or extensively drug-resistant tuberculosis, treatment of delamanid in combination with WHO-recommended optimised background treatment regimen was associated with improved treatment outcomes and reduced mortality rate [A31965]. Spontaneous resistance to delamanid was observed during treatment, where mutation in one of the 5 F420 coenzymes responsible for bioactivation of delamanid contributes to this effect [L1407]. Delamanid is approved by the EMA and is marketed under the trade name Deltyba as oral tablets. It is marketed by Otsuka Pharmaceutical Co., Ltd (Tokyo, Japan). |
| Indications and Usage |
Indicated for use as part of an appropriate combination regimen for pulmonary multi-drug resistant tuberculosis (MDR-TB) in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability [L1407]. |
| Marketing Status |
approved; investigational |
| ATC Code |
J04AK06 |
| DrugBank ID |
DB11637
|
| KEGG ID |
D09785
|
| MeSH ID |
C516022
|
| PubChem ID |
6480466
|
| TTD Drug ID |
D0S3NU
|
| NDC Product Code |
Not Available |
| UNII |
8OOT6M1PC7
|
| Synonyms |
OPC-67683 | delamanid |
|
| Chemical Information |
| Molecular Formula |
C25H25F3N4O6 |
| CAS Registry Number |
681492-22-8 |
| SMILES |
CC1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F |
| Chemical Structure |
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| ADRs Induced by Drug |
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