Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Difluprednate
Drug ID BADD_D00667
Description Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Indications and Usage For the treatment of inflammation and pain associated with ocular surgery.
Marketing Status approved
ATC Code D07AC19
DrugBank ID DB06781
KEGG ID D01266
MeSH ID C015808
PubChem ID 443936
TTD Drug ID D01ZOG
NDC Product Code 26251-0003; 69097-341; 0078-0862; 46439-8738; 76282-708; 46439-8739; 49803-002
UNII S8A06QG2QE
Synonyms difluprednate | ENV905 | C.M.9155 | Epitopic
Chemical Information
Molecular Formula C27H34F2O7
CAS Registry Number 23674-86-4
SMILES CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Foreign body sensation in eyes06.01.01.0060.000716%Not Available
Conjunctival hyperaemia06.04.01.004--Not Available
Anterior chamber flare06.04.10.003--Not Available
Ciliary hyperaemia06.04.03.004--Not Available
Eyelid margin crusting23.03.03.029; 06.04.04.005--Not Available
Eye pruritus06.04.05.0060.000716%Not Available
Ocular discomfort06.08.03.0080.001179%Not Available
Nerve injury17.02.10.007; 12.01.12.002--Not Available
Anterior chamber cell06.04.10.001--Not Available
Corneal thinning06.06.03.009--Not Available
Eyelid irritation23.03.04.023; 06.04.04.007--Not Available
Scleral hyperaemia06.04.07.003--Not Available
Corneal disorder06.08.01.0040.001284%Not Available
Sensation of foreign body08.01.09.002--Not Available
Application site discomfort12.07.01.034; 08.02.01.034--Not Available
Ulcerative keratitis06.04.02.004; 10.02.01.0210.000526%
Treatment failure08.06.01.0170.000716%Not Available
Reproductive toxicity21.10.05.013; 12.03.01.052--Not Available
Open globe injury06.11.01.008; 12.01.04.016--Not Available
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