Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dobutamine
Drug ID BADD_D00697
Description A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Indications and Usage Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Marketing Status approved
ATC Code C01CA07
DrugBank ID DB00841
KEGG ID D03879
MeSH ID D004280
PubChem ID 36811
TTD Drug ID D0J7RK
NDC Product Code 70436-203; 51662-1337; 62778-350; 0409-2344; 51662-1330; 14335-172; 14335-171; 0143-9141
UNII 3S12J47372
Synonyms Dobutamine | Dobucor | Dobuject | Dobutamin Fresenius | Dobutamin Hexal | Dobutamin Solvay | Dobutamin-ratiopharm | Dobutamin ratiopharm | Dobutamina Inibsa | Dobutamina Rovi | Posiject | Dobutamine Hydrobromide | Hydrobromide, Dobutamine | Dobutamine Hydrochloride | Hydrochloride, Dobutamine | Dobutamine Lactobionate | Lactobionate, Dobutamine | Dobutamine Tartrate | Tartrate, Dobutamine | Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer | Dobutamine Tartrate (1:1), (R-(R*,R*))-Isomer | Dobutamine, (-)-Isomer | Dobutamine, Phosphate (1:1) Salt (+)-Isomer | Dobutrex | Lilly 81929 | Oxiken | Dobutamine Phosphate (1:1) Salt, (-)-Isomer | Dobutamine (+)-Isomer
Chemical Information
Molecular Formula C18H23NO3
CAS Registry Number 34368-04-2
SMILES CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000169%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000085%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Atrial fibrillation02.03.03.0020.003129%
Atrioventricular block complete02.03.01.0030.000127%
Blood pressure systolic increased13.14.03.006--Not Available
Bradycardia02.03.02.0020.000085%Not Available
Cardiac arrest02.03.04.0010.000169%
Cardiac failure02.05.01.0010.000127%
Cardiogenic shock24.06.02.006; 02.05.01.0030.000254%Not Available
Cardiomyopathy02.04.01.0010.000127%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Coronary artery disease24.04.04.006; 02.02.01.0010.000085%Not Available
Death08.04.01.0010.010868%
Dyspnoea02.11.05.003; 22.02.01.004--
Eosinophilic myocarditis02.04.03.002; 01.02.04.0070.000127%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.000127%
Headache17.14.01.001--
Hypertension24.08.02.0010.000254%
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Low cardiac output syndrome02.05.01.0080.000085%Not Available
Myocardial infarction02.02.02.007; 24.04.04.0090.000127%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000592%Not Available
Nausea07.01.07.001--
Palpitations02.11.04.012--
Phlebitis24.12.03.004; 12.02.01.002--
Pruritus23.03.12.001--
Respiratory failure22.02.06.002; 14.01.04.0030.000127%
Restrictive cardiomyopathy02.04.01.0050.000085%
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ADReCS-Target
Drug Name ADR Term Target
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