ADReCS

Pharmaceutical Information

Drug Name	Dobutamine
Drug ID	BADD_D00697
Description	A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Indications and Usage	Indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Marketing Status	approved
ATC Code	C01CA07
DrugBank ID	DB00841
KEGG ID	D03879
MeSH ID	D004280
PubChem ID	36811
TTD Drug ID	D0J7RK
NDC Product Code	70436-203; 51662-1337; 62778-350; 0409-2344; 51662-1330; 14335-172; 14335-171; 0143-9141
UNII	3S12J47372
Synonyms	Dobutamine \| Dobucor \| Dobuject \| Dobutamin Fresenius \| Dobutamin Hexal \| Dobutamin Solvay \| Dobutamin-ratiopharm \| Dobutamin ratiopharm \| Dobutamina Inibsa \| Dobutamina Rovi \| Posiject \| Dobutamine Hydrobromide \| Hydrobromide, Dobutamine \| Dobutamine Hydrochloride \| Hydrochloride, Dobutamine \| Dobutamine Lactobionate \| Lactobionate, Dobutamine \| Dobutamine Tartrate \| Tartrate, Dobutamine \| Dobutamine Tartrate (1:1), (S-(R,R))-Isomer \| Dobutamine Tartrate (1:1), (R-(R,R))-Isomer \| Dobutamine, (-)-Isomer \| Dobutamine, Phosphate (1:1) Salt (+)-Isomer \| Dobutrex \| Lilly 81929 \| Oxiken \| Dobutamine Phosphate (1:1) Salt, (-)-Isomer \| Dobutamine (+)-Isomer

Chemical Information

Molecular Formula	C18H23NO3
CAS Registry Number	34368-04-2
SMILES	CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Acute myocardial infarction	02.02.02.001; 24.04.04.001	0.000169%		Not Available
Acute pulmonary oedema	22.01.03.005; 02.05.02.004	0.000085%		Not Available
Angina pectoris	24.04.04.002; 02.02.02.002	-	-
Atrial fibrillation	02.03.03.002	0.003129%
Atrioventricular block complete	02.03.01.003	0.000127%
Blood pressure systolic increased	13.14.03.006	-	-	Not Available
Bradycardia	02.03.02.002	0.000085%		Not Available
Cardiac arrest	02.03.04.001	0.000169%
Cardiac failure	02.05.01.001	0.000127%
Cardiogenic shock	24.06.02.006; 02.05.01.003	0.000254%		Not Available
Cardiomyopathy	02.04.01.001	0.000127%		Not Available
Chest pain	08.01.08.002; 02.02.02.011; 22.12.02.003	-	-	Not Available
Coronary artery disease	24.04.04.006; 02.02.01.001	0.000085%		Not Available
Death	08.04.01.001	0.010868%
Dyspnoea	02.11.05.003; 22.02.01.004	-	-
Eosinophilic myocarditis	02.04.03.002; 01.02.04.007	0.000127%		Not Available
Haemorrhage intracranial	24.07.04.003; 17.08.01.008	0.000127%
Headache	17.14.01.001	-	-
Hypertension	24.08.02.001	0.000254%
Hypokalaemia	14.05.03.002	-	-
Hypotension	24.06.03.002	-	-
Low cardiac output syndrome	02.05.01.008	0.000085%		Not Available
Myocardial infarction	24.04.04.009; 02.02.02.007	0.000127%
Myocardial ischaemia	24.04.04.010; 02.02.02.008	0.000592%		Not Available
Nausea	07.01.07.001	-	-
Palpitations	02.11.04.012	-	-
Phlebitis	24.12.03.004; 12.02.01.002	-	-
Pruritus	23.03.12.001	-	-
Respiratory failure	22.02.06.002; 14.01.04.003	0.000127%
Restrictive cardiomyopathy	02.04.01.005	0.000085%

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