| Pharmaceutical Information |
| Drug Name |
Docosanol |
| Drug ID |
BADD_D00700 |
| Description |
Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. |
| Indications and Usage |
For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters). |
| Marketing Status |
approved; investigational |
| ATC Code |
D06BB11 |
| DrugBank ID |
DB00632
|
| KEGG ID |
D03884
|
| MeSH ID |
C529236
|
| PubChem ID |
12620
|
| TTD Drug ID |
D00AOJ
|
| NDC Product Code |
11822-3927; 30142-981; 0135-0300; 55301-877; 55910-963; 0363-2981; 0536-1379; 79903-011; 81522-922; 24196-183; 11673-926; 21130-422; 21130-823; 21922-023; 49035-259; 62011-0433; 62332-682; 0363-9222; 70677-1046; 79903-118; 11822-3951; 55910-722; 68016-052; 71589-019; 72476-492; 0591-2981; 37808-765; 41250-932; 51316-763; 55910-550; 70600-010; 30142-869; 61269-989; 79481-9220; 51927-5068; 59726-924; 0363-9220; 69575-4024; 11822-0951; 11822-6500; 46122-624; 70000-0517; 11822-3977; 11822-4763; 37808-223; 41163-724; 55301-922; 61269-981; 0363-6510; 0363-8877; 76162-900; 81522-923; 15894-0036; 59285-016; 59651-490; 63379-085; 11673-846; 0135-0200; 79481-0065; 30142-322; 41163-722; 41250-867; 46122-681; 55319-922 |
| UNII |
9G1OE216XY
|
| Synonyms |
docosanol | behenyl alcohol | 1-docosanol | IK.2 | Abreva |
|
| Chemical Information |
| Molecular Formula |
C22H46O |
| CAS Registry Number |
661-19-8 |
| SMILES |
CCCCCCCCCCCCCCCCCCCCCCO |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Acne | 23.02.01.001 | - | - | Not Available | | Application site reaction | 12.07.01.006; 08.02.01.006 | - | - | Not Available | | Dermatitis | 23.03.04.002 | - | - | Not Available | | Dry skin | 23.03.03.001 | - | - | | | Headache | 17.14.01.001 | - | - | | | Pruritus | 23.03.12.001 | - | - | | | Rash | 23.03.13.001 | - | - | Not Available |
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