Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dofetilide
Drug ID BADD_D00701
Description Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Indications and Usage For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Marketing Status approved; investigational
ATC Code C01BD04
DrugBank ID DB00204
KEGG ID D00647
MeSH ID C063533
PubChem ID 71329
TTD Drug ID D0NW3X
NDC Product Code 0069-5810; 51862-005; 69452-133; 63190-0670; 42291-413; 42794-044; 51862-125; 14096-192; 29902-0014; 42291-411; 69452-131; 72205-041; 72664-229; 49812-0261; 16714-842; 42794-046; 47335-061; 47335-063; 59651-120; 72603-130; 72603-132; 16714-840; 16729-490; 16729-492; 59651-118; 69539-131; 0069-5820; 69452-132; 72664-231; 0904-6681; 50137-4245; 42291-412; 42794-045; 51862-025; 59651-119; 69539-130; 72664-230; 0904-6682; 0904-6683; 59651-038; 63190-0680; 0069-5800; 72205-040; 42413-0170; 63278-1079; 76055-0013; 16714-841; 16729-491; 69539-132; 72205-039; 72603-131; 69766-022; 47335-062
UNII R4Z9X1N2ND
Synonyms dofetilide | 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane | 1-MSPMPE | Tikosyn | UK 68798 | UK-68,798
Chemical Information
Molecular Formula C19H27N3O5S2
CAS Registry Number 115256-11-6
SMILES CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tachycardia02.03.02.0070.000896%Not Available
Therapeutic response unexpected08.06.01.0010.000288%Not Available
Thirst14.03.02.007; 08.01.09.0210.000288%Not Available
Torsade de pointes02.03.04.0050.002546%Not Available
Transient ischaemic attack24.04.06.005; 17.08.04.0010.000228%
Tremor17.01.06.0020.001235%
Unresponsive to stimuli17.02.05.0310.000228%Not Available
Urinary tract disorder20.08.01.0010.000186%Not Available
Urinary tract infection11.01.14.004; 20.08.02.001--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.0070.000524%Not Available
Ventricular fibrillation02.03.04.0080.000651%
Ventricular tachycardia02.03.04.0100.002157%
Visual impairment06.02.10.0130.000702%Not Available
Wheezing22.03.01.0090.000186%
Mental status changes19.07.01.0010.000228%Not Available
Hypoacusis04.02.01.0060.000288%
Ventricular hypokinesia02.04.02.0130.000085%Not Available
Blood pressure inadequately controlled24.06.01.0070.000288%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Cardiac flutter02.03.02.0120.000186%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000169%Not Available
Aortic disorder24.03.04.0040.000085%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.000575%
Abdominal hernia07.16.06.0050.000085%Not Available
Cardiac disorder02.11.01.0030.000922%Not Available
Infarction24.04.02.017--Not Available
Disease recurrence08.01.03.0500.000330%Not Available
Drug intolerance08.06.01.0130.000803%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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