| Drug Name |
Dolasetron mesylate |
| Drug ID |
BADD_D00703 |
| Description |
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors. |
| Indications and Usage |
For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses of chemotherapy. Also used for the prevention of postoperative nausea and vomiting. This drug can be used intravenously for the treatment of postoperative nausea and vomiting. |
| Marketing Status |
approved; investigational |
| ATC Code |
A04AA04 |
| DrugBank ID |
DB00757
|
| KEGG ID |
D00725
|
| MeSH ID |
C060344
|
| PubChem ID |
3033817
|
| TTD Drug ID |
D00YLW
|
| NDC Product Code |
62147-0095; 63827-1007; 62147-0094 |
| UNII |
U3C8E5BWKR
|
| Synonyms |
dolasetron | 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)- | octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate | indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one | dolasetron mesylate | dolasetron mesylate monohydrate | 1H-indole-3-carboxylic acid-trans-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester methanesulfonate | dolasetron mesilate monohydrate | 1H-indole-3-carboxylic acid, (6R,9AS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, rel-, methanesulfonate, hydrate (1:1:1) | Anzemet | MDL 73,147EF | MDL-73147EF | MDL 73147EF |
